Abstract
The guinea pig model of disease has been considered synonymous with the experimental laboratory animal since the nineteenth century. Recently we have reviewed the use of this species in models of bacterial infectious disease. The present review extends to viral diseases for which the guinea pig is less frequently considered the relevant animal model. The use of the guinea pig as a laboratory animal, aspects of immunology, viral pathogens and host-pathogen models are discussed. As a small and relatively inexpensive model for infection and immunity the guinea pig has a significant future but there are substantial requirements for development of validated quantitative analytical methods for immunological and disease biomarkers if it is to reach its potential.
Keywords: guinea pig, immunology, viruses, animal model, antiviral drugs, bacterial diseases, pathogens, delayed-type hypersensivity, Baltimore virus, genome
Current Drug Targets
Title: Guinea Pig Model of Infectious Disease - Viral Infections
Volume: 12 Issue: 7
Author(s): Anthony J. Hickey
Affiliation:
Keywords: guinea pig, immunology, viruses, animal model, antiviral drugs, bacterial diseases, pathogens, delayed-type hypersensivity, Baltimore virus, genome
Abstract: The guinea pig model of disease has been considered synonymous with the experimental laboratory animal since the nineteenth century. Recently we have reviewed the use of this species in models of bacterial infectious disease. The present review extends to viral diseases for which the guinea pig is less frequently considered the relevant animal model. The use of the guinea pig as a laboratory animal, aspects of immunology, viral pathogens and host-pathogen models are discussed. As a small and relatively inexpensive model for infection and immunity the guinea pig has a significant future but there are substantial requirements for development of validated quantitative analytical methods for immunological and disease biomarkers if it is to reach its potential.
Export Options
About this article
Cite this article as:
J. Hickey Anthony, Guinea Pig Model of Infectious Disease - Viral Infections, Current Drug Targets 2011; 12 (7) . https://dx.doi.org/10.2174/138945011795677827
DOI https://dx.doi.org/10.2174/138945011795677827 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Synthesis and Mosquiticidal Activity of Novel Hydrazone Containing Pyrimidine Derivatives against Aedes aegypti
Letters in Drug Design & Discovery Approaches to the Pharmacological Modulation of Plasmacytoid Dendritic Cells
Endocrine, Metabolic & Immune Disorders - Drug Targets Viral Encephalitis in Adults: A Narrative Review
Reviews on Recent Clinical Trials Efficacy and Toxicity of Clioquinol Treatment and A-beta42 Inoculation in the APP/PSI Mouse Model of Alzheimer's Disease
Current Alzheimer Research MicroRNAs: Key Players in Microglia and Astrocyte Mediated Inflammation in CNS Pathologies
Current Medicinal Chemistry Gut Homing Molecule Regulation of the Pathogenesis and Treatment of Inflammatory Bowel Diseases
Inflammation & Allergy - Drug Targets (Discontinued) ABC Transporters in Neurological Disorders: An Important Gateway for Botanical Compounds Mediated Neuro-Therapeutics
Current Topics in Medicinal Chemistry Schizophrenia Patient Shows a Rare Interleukin 15 Receptor alpha Variant Disrupting Signal Transduction
Current Molecular Medicine Antiviral Agents in the Prevention and Treatment of Virus-Induced Diabetes
Anti-Infective Agents in Medicinal Chemistry Brain Aging and Disorders of the Central Nervous System: Kynurenines and Drug Metabolism
Current Drug Metabolism Reverse Vaccinology: An Epitope Based Approach to Design Vaccines
Current Bioinformatics Advancement in Nanoparticle-based Biosensors for Point-of-care <i>In vitro</i> Diagnostics
Current Topics in Medicinal Chemistry Treatment of Viral Encephalitis
Central Nervous System Agents in Medicinal Chemistry Immunization for Persons Infected with Human Immunodeficiency Virus
Current HIV Research HSV Amplicons: Neuro Applications
Current Gene Therapy The Application of Micro-Analytical Techniques to Biomedical Analysis
Current Pharmaceutical Analysis How Computational Studies of Mosquito Repellents Contribute to the Control of Vector Borne Diseases
Current Computer-Aided Drug Design A Review on Response of Immune System in Spinal Cord Injury and Therapeutic Agents useful in Treatment
Current Pharmaceutical Biotechnology Defining and Regulating Acute Inflammatory Lesion Formation during the Pathogenesis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
CNS & Neurological Disorders - Drug Targets Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms
Current Genomics