Comparative Study of Apoptosis Induced by H2O2 and NO: Limitation of Apoptosis Induced by NO Due to Slower Recovery of Activity of NOModified Caspase

Ja-Eun      Kim; Heeyoung      Seok; Pratap      Karki; Jung   S.   Lee; Song   Y.   Shin; Byungyun      Cho; Il-Seon      Park

Abstract

Both H2O2 and NO can act as apoptogens, triggering apoptosis in many cells. They are also well known inhibitors of caspases, essential enzymes in apoptosis. The differences between these two agents as apoptosis inducers and how caspases mediate apoptosis with these inhibitory agents is still unclear. Consistent with the previous reports, these two agents induced apoptosis accompanied by caspase activation with limitation of all apoptotic events for NO. It was found that NO-modified caspase-3 showed a slower recovery of its activity in the presence of the reducing agents compared to that of H2O2 modification. This is one possible cause of the limited apoptosis in the case of NO.

Keywords: H2O2, NO, apoptosis, caspase

« Previous Next »

Rights & Permissions Print Export Cite as

Protein & Peptide Letters

Title: Comparative Study of Apoptosis Induced by H2O2 and NO: Limitation of Apoptosis Induced by NO Due to Slower Recovery of Activity of NOModified Caspase

Volume: 13 Issue: 4

Author(s): Ja-Eun Kim, Heeyoung Seok, Pratap Karki, Jung S. Lee, Song Y. Shin, Byungyun Cho and Il-Seon Park

Affiliation:

Keywords: H2O2, NO, apoptosis, caspase

Abstract: Both H2O2 and NO can act as apoptogens, triggering apoptosis in many cells. They are also well known inhibitors of caspases, essential enzymes in apoptosis. The differences between these two agents as apoptosis inducers and how caspases mediate apoptosis with these inhibitory agents is still unclear. Consistent with the previous reports, these two agents induced apoptosis accompanied by caspase activation with limitation of all apoptotic events for NO. It was found that NO-modified caspase-3 showed a slower recovery of its activity in the presence of the reducing agents compared to that of H2O2 modification. This is one possible cause of the limited apoptosis in the case of NO.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Kim Ja-Eun, Seok Heeyoung, Karki Pratap, Lee S. Jung, Shin Y. Song, Cho Byungyun and Park Il-Seon, Comparative Study of Apoptosis Induced by H2O2 and NO: Limitation of Apoptosis Induced by NO Due to Slower Recovery of Activity of NOModified Caspase, Protein & Peptide Letters 2006; 13(4) . https://dx.doi.org/10.2174/092986606775974401