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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

The Early Events of α-Synuclein Oligomerization Revealed by Photo- Induced Cross-Linking

Author(s): Hong-Tao Li, Xiao-Jing Lin, Yuan-Yuan Xie and Hong-Yu Hu

Volume 13, Issue 4, 2006

Page: [385 - 390] Pages: 6

DOI: 10.2174/092986606775974384

Price: $65


Assembly of α-synuclein (α-Syn) into neurotoxic oligomers and fibrils is an important pathogenic feature of Parkinsons disease. Studying the early events of α-Syn aggregation, such as oligomerization and nucleation, is indispensable to understanding the complicated process. Here, photo-induced cross-linking of unmodified proteins (PICUP) technique is applied to elucidate the early-stage oligomerization of α-Syn. Results show that α-Syn in solution exhibits a mixture of various species, including at least monomers, dimers and trimers. Aggregation of α-Syn probably originates from the dimeric and trimeric seeds. Furthermore, the N-terminal amphipathic region is proposed to be required for the oligomerization (dimerization and trimerization) process. This observation may extend our knowledge on the early events of α-Syn aggregation and the neurotoxic aggregation species.

Keywords: α-synuclein, oligomerization, PICUP, dimmer, trimer

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