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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Comparative Studies of the Antioxidant Effects of Cis- and Trans- Resveratrol

Author(s): F. Orallo

Volume 13, Issue 1, 2006

Page: [87 - 98] Pages: 12

DOI: 10.2174/092986706775197962

Price: $65


Resveratrol (3,4,5-trihydroxystilbene, RESV) is a natural phenolic compound that exists as cis and trans isomers [c-RESV or (Z)-RESV and t-RESV or (E)-RESV, respectively]. t-RESV is a natural component of Vitis vinifera L. (Vitaceae), abundant in the skin of grapes (but not in the flesh) and in the leaf epidermis, and present in wines, especially red wines. In in vitro, ex vivo and in vivo experiments t-RESV exhibits a number of biological activities, including anti-inflammatory and anticarcinogenic properties. RESV also exists in wines as a cis isomer, which (unlike t-RESV) is not currently available commercially; as a result, little is known about this isomers pharmacological activity. In this review, I will focus on the few comparative studies of the antioxidant effects of the two RESV isomers in different experimental models.

Keywords: Resveratrol isomers, NAD(P)H oxidase, xanthine oxidase, inducible nitric oxide synthase, murine macrophages, antioxidant activity, free radicals, wine

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