Inhibitors and Modulators of β- and γ-Secretase

Title: Inhibitors and Modulators of β- and γ-Secretase

Volume: 6 Issue: 4

Author(s): Boris Schmidt, Stefanie Baumann, Hannes A. Braun and Gregor Larbig

Affiliation:

Keywords: Alzheimer's disease, secretase, aspartic protease, inhibitor, presenilin

Abstract: Most gene mutations associated with Alzheimers disease point to the metabolism of amyloid precursor protein as potential cause. The β- and γ-secretases are two executioners of amyloid precursor protein processing resulting in amyloid β. Significant progress has been made in the selective inhibition of both proteases, regardless of structural information for γ-secretase. Several peptidic and non-peptidic leads were identified and first drug candidates are in clinical trials. This review focuses on the developments since 2003.

Cite this article as:

Schmidt Boris, Baumann Stefanie, Braun A. Hannes and Larbig Gregor, Inhibitors and Modulators of β- and γ-Secretase, Current Topics in Medicinal Chemistry 2006; 6(4) . https://dx.doi.org/10.2174/156802606776287027