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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Inhibitors and Modulators of β- and γ-Secretase

Author(s): Boris Schmidt, Stefanie Baumann, Hannes A. Braun and Gregor Larbig

Volume 6, Issue 4, 2006

Page: [377 - 392] Pages: 16

DOI: 10.2174/156802606776287027

Price: $65


Most gene mutations associated with Alzheimers disease point to the metabolism of amyloid precursor protein as potential cause. The β- and γ-secretases are two executioners of amyloid precursor protein processing resulting in amyloid β. Significant progress has been made in the selective inhibition of both proteases, regardless of structural information for γ-secretase. Several peptidic and non-peptidic leads were identified and first drug candidates are in clinical trials. This review focuses on the developments since 2003.

Keywords: Alzheimer's disease, secretase, aspartic protease, inhibitor, presenilin

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