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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Does More MnSOD Mean More Hydrogen Peroxide?

Author(s): Lee Ann MacMillan-Crow and John P. Crow

Volume 11, Issue 2, 2011

Page: [178 - 180] Pages: 3

DOI: 10.2174/187152011795255939

Price: $65


Superoxide dismutases (SODs) are a family of important antioxidant enzymes that catalyze the conversion of superoxide to hydrogen peroxide and oxygen. Hydrogen peroxide is then detoxified by a host of antioxidant enzymes. A common misconception is that the increased MnSOD levels will result in increased hydrogen peroxide levels. Herein we offer some potential reasons for this confusion, as well as some potential resolutions. Data are offered that demonstrate the ability of MnSOD, in the presence of nitric oxide, to utilize hydrogen peroxide to produce superoxide and the more toxic oxidant, peroxynitrite.

Keywords: MnSOD, superoxide, hydrogen peroxide, nitric oxide, peroxynitrite, oxidant-sensitive fluorophore, metalloproteinases, H2O2, ONOO, nanomolar concentrations, DCDHF, proliferation, ischemia/reperfusion injury, horseradish peroxidase or HRP

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