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Current Drug Delivery


ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

Peptide-Based Subunit Nanovaccines

Author(s): Mariusz Skwarczynski and Istvan Toth

Volume 8, Issue 3, 2011

Page: [282 - 289] Pages: 8

DOI: 10.2174/156720111795256192

Price: $65


Classical vaccines incorporating live or attenuated microorganisms possess several disadvantages and cannot be applied against cancer and some pathogens. Modern vaccines utilizing immunogenic subunits derived from a particular pathogen are able to overcome these obstacles but need a specific delivery system for their efficacy. Nanotechnology has opened a new window into these delivery methodologies. A nano-sized formulation of subunit vaccines has been proven to be very effective in inducing cellular and humoral immune responses. Here, we review a number of peptide vaccine delivery strategies based on nanoparticles composed of polymers, peptides, lipids, and inorganic materials.

Keywords: Subunit vaccine, peptide epitope, nanotechnology, nanoparticles, infectious diseases, Nanovaccine, autoimmunity, lipid carriers, inorganic materials, pathogens

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