Pt(II) vs Pd(II) Polyamine Complexes as New Anticancer Drugs: A Structure- Activity Study

Title: Pt(II) vs Pd(II) Polyamine Complexes as New Anticancer Drugs: A Structure- Activity Study

Volume: 3 Issue: 3

Author(s): S. M. Fiuza, A. M. Amado, Paulo J. Oliveira, Vilma A. Sardao, L. A.E.B. de Carvalho and M. P.M. Marques

Affiliation:

Keywords: Pt(II), Pd(II), spermidine, anticancer drugs, squamous tongue epithelioma

Abstract: Two homologous trinuclear polyamine chelates with either Pt(II) (Ia) or Pd(II) (Ib) were screened for their anticancer properties. Their growth-inhibition activity towards a human tongue epithelioma (HSC-3) was assessed in vitro, and the effect of the cation alteration was determined (IC50 =32 μM for Ib vs 66 μM for Ia).

Cite this article as:

Fiuza M. S., Amado M. A., Oliveira J. Paulo, Sardao A. Vilma, de Carvalho A.E.B. L. and Marques P.M. M., Pt(II) vs Pd(II) Polyamine Complexes as New Anticancer Drugs: A Structure- Activity Study, Letters in Drug Design & Discovery 2006; 3(3) . https://dx.doi.org/10.2174/157018006776286989