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Combinatorial Chemistry & High Throughput Screening


ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

High Throughput Tools for the Study of Protein-Nanostructured Surface Interaction

Author(s): Pasquale Emanuele Scopelliti, Gero Bongiorno and Paolo Milani

Volume 14 , Issue 3 , 2011

Page: [206 - 216] Pages: 11

DOI: 10.2174/138620711794728770

Price: $65


The aim of this review is to describe and to analyze the ingredients that are necessary in order to develop a robust and effective experimental approach for the high throughput characterization of protein-nanostructured surface interaction. In the first part of this paper we review the nanostructured surface synthesis methods that are potentially able to create nanostructured inorganic surface libraries. In the second part, we address another fundamental aspect consisting in the availability of high throughput proteins detection methods. We describe in details new emerging analytical tools compatible with nanostructured surfaces, analyzing different possible strategies, depending on the objective of the experiment and on the library format.

Keywords: Biomaterials, nanotechnology, titanium, protein adsorption, tissue engineering, biological media, Gradient, Microarray, physical vapor deposition, evaporation, high-density chips

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