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Combinatorial Chemistry & High Throughput Screening


ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Glyconanoparticles for Biomedical Applications

Author(s): Chang-Ming Dong

Volume 14 , Issue 3 , 2011

Page: [173 - 181] Pages: 9

DOI: 10.2174/138620711794728716

Price: $65


Over the past two decades, glycosylated nanoparticles (i.e., glyconanoparticles having sugar residues on the surface) received much attention for biomedical applications such as bioassays and targeted drug delivery. This minireview focuses on three aspects: (1) glycosylated gold nanoparticles, (2) glycosylated quantum dots, and (3) glyconanoparticles self-assembled from amphiphilic glycopolymers. The synthetic methods and the multivalent interactions between glyconanoparticles and lectins is shortly illustrated.

Keywords: Glyconanoparticles, glycopolymers, biomolecular recognition, bioassays, targeted drug delivery, multivalent interactions, biological receptors, cell adhesion, carbohydrate-protein interactions, magnetic resonance imaging, colloidal stability, water-solubility, biodegradable, glycopolymer

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