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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Targeting Double Stranded DNA with Peptide Nucleic Acid (PNA)

Author(s): Peter E. Nielsen

Volume 8, Issue 5, 2001

Page: [545 - 550] Pages: 6

DOI: 10.2174/0929867003373373

Price: $65


PNA (peptide nucleic acid) is a DNA mimic with a pseudopeptide (polyamide) backbone which can be used to target double stranded DNA with high sequence specificity. PNA therefore has great potential in the development of biomolecular tools for manipulation of DNA as well as for the development of DNA targeted gene therapeutic drugs. The status of this field is discussed in terms of PNA binding modes and mechanism as well as applications.

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