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Current Pharmaceutical Analysis


ISSN (Print): 1573-4129
ISSN (Online): 1875-676X

Analysis and Determination of Anti-diabetes Drug Acarbose and its Structural Analogs

Author(s): Ya-Jun Wang, Yu-Guo Zheng, Ya-Ping Xue, Yuan-Shan Wang and Yin-Chu Shen

Volume 7, Issue 1, 2011

Page: [12 - 20] Pages: 9

DOI: 10.2174/157341211794708721

Price: $65


Acarbose is a clinically useful drug for the treatment of type II insulin-independent diabetes as a hypoglycemic agent. This minireview summarized detection and separation methods for the analysis and determination of anti-diabetes drug acarbose and its structural analogs, including HPLC, enzyme-based biosensor and capillary electrophoresis. Besides the protocol, principle behind each technique is presented together with its strengths and weaknesses. Finally, we analyze the future trends in the acarbose analysis.

Keywords: Diabetes, Acarbose, Analysis, Liquid chromatography, Capillary electrophoresis, Biosensor, α-glucosidase Inhibitor, Non-Insulin-Dependent Diabetes Mellitus (NIDDM), Refractive Index Detection (RID), Evaporative Light Scattering Detection (ELSD), Normal Phase Liquid Chromatography (NPLC)

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