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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry


ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

Alpha-1 Antitrypsin: It’s Role in Health and Disease

Author(s): Mohammad Hashemi, Pawan Sharma, Mehdi Eshraghi, Mohammad Naderi, Abdolkarim Moazeni-Roodi, Hamid Mehrabifar and Mohsen Taheri

Volume 9, Issue 4, 2010

Page: [279 - 288] Pages: 10

DOI: 10.2174/1871523011009040279

Price: $65


Alpha-1 Antitrypsin (AAT) is a 52 kDa glycoprotein that is principally synthesized by the liver. It is the archetype of the serine protease inhibitor (Serpin) superfamily of proteins, which has a major role in inactivating neutrophil elastase and other proteases to retain protease–antiprotease equilibrium. AAT deficiency is a rare monogenic disorder characterized by low levels of AAT in serum and the lungs and it is well known to be associated with emphysema and liver disease. Inadequate knowledge of AAT deficiency might be due to under-recognition of this protein. To date, the exact role of AAT deficiency in various diseases has not been extensively elucidated. In this review, the current knowledge regarding the role AAT in various disorders will be discussed.

Keywords: Alpha 1-antitrypsin, serine protease inhibitors, SERPIN.

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