Generic placeholder image

Current Cancer Drug Targets


ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Anti-Angiogenic Therapies for Children with Cancer

Author(s): N. Andre, A. Verschuur, J. Rossler and J. Sterba

Volume 10, Issue 8, 2010

Page: [879 - 889] Pages: 11

DOI: 10.2174/156800910793357899

Price: $65


Tumor angiogenesis, i.e. the development of neovascularisation in and around solid tumors, plays a key role in the local and distant growth of cancer and anti-angiogenic treatments are now established strategies to treat cancer patients. Specific inhibitors of angiogenesis such as bevacizumab or receptor tyrosine kinase inhibitors targeting VEGFR or PDGFR are now in clinical trials and are being increasingly validated for the treatment of poor prognostic cancers. Other anti-angiogenic strategies such as cilengitide or metronomic chemotherapy (low-dose anti-angiogenic chemotherapy) have been developed to treat certain types of adult cancer. In children, the clinical potential of anti-angiogenic approach is still in an early stage of investigation. This review will focus on the role of angiogenesis in pediatric solid tumors and will describe the pre-clinical and clinical experience with several anti-angiogenic compounds as a potential treatment for children with cancer.

Keywords: Children, oncology, angiogenesis, treatment, metronomic, VEGF, Tyrosine kinase inhibitors.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy