Abstract
The etiology of multiple sclerosis (MS) remains unclear. To determine if autoantibodies to myelin basic protein (MBP) are produced during parvovirus B19 infection, A competitive ELISA was performed using plasma from MS patients exhibiting high IgG titers for parvovirus. Our results showed the addition of MBP decreased the binding of IgG to B19 antigen in A dose dependent fashion suggesting A possible link between parvovirus B19 and A subset of patients with clinical MS.
Keywords: Myelin basic protein, Parvovirus B19, Multiple sclerosis, Demyelination, Autoantibody, CNS
Protein & Peptide Letters
Title: Autoantibody Reaction to Myelin Basic Protein by Plasma Parvovirus B19 IgG in MS Patients
Volume: 13 Issue: 2
Author(s): Gregory Thomas, Leonard Rael, Rick Shimonkevitz, Isaac Melamed and David Bar-Or
Affiliation:
Keywords: Myelin basic protein, Parvovirus B19, Multiple sclerosis, Demyelination, Autoantibody, CNS
Abstract: The etiology of multiple sclerosis (MS) remains unclear. To determine if autoantibodies to myelin basic protein (MBP) are produced during parvovirus B19 infection, A competitive ELISA was performed using plasma from MS patients exhibiting high IgG titers for parvovirus. Our results showed the addition of MBP decreased the binding of IgG to B19 antigen in A dose dependent fashion suggesting A possible link between parvovirus B19 and A subset of patients with clinical MS.
Export Options
About this article
Cite this article as:
Thomas Gregory, Rael Leonard, Shimonkevitz Rick, Melamed Isaac and Bar-Or David, Autoantibody Reaction to Myelin Basic Protein by Plasma Parvovirus B19 IgG in MS Patients, Protein & Peptide Letters 2006; 13 (2) . https://dx.doi.org/10.2174/092986606775101715
DOI https://dx.doi.org/10.2174/092986606775101715 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
A Review on Rheumatoid Arthritis Interventions and Current Developments
Current Drug Targets Free Radicals Generated by Post-Prandial Oxidative Burst in the Early Alterations of Vascular Contractility
Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued) Antibody-Mediated Endothelial Cell Damage Via Nitric Oxide
Current Pharmaceutical Design Pro-Inflammatory Gene Variants in Myocardial Infarction and Longevity: Implications for Pharmacogenomics
Current Pharmaceutical Design Imatinib Mesylate (Gleevec©): Targeted Therapy Against Cancer with Immune Properties
Endocrine, Metabolic & Immune Disorders - Drug Targets Antineutrophil Cytoplasmic Antibody in Lupus Nephritis: Correlation with Clinicopathological Characteristics and Disease Activity
Current Rheumatology Reviews Glucose Blood Levels as a Therapeutic Target in Acute Ischaemic Stroke Setting
Current Topics in Medicinal Chemistry The Role of Infections in the Pathogenesis of Autoimmune Diseases
Current Drug Targets - Inflammation & Allergy Blood Coagulation as an Intrinsic Pathway for Proinflammation: A Mini Review
Inflammation & Allergy - Drug Targets (Discontinued) Expression, Distribution and Regulation of Phosphodiesterase 5
Current Pharmaceutical Design An Overview of Novel Coronavirus Disease 2019: A Global Havoc
Coronaviruses Current Therapeutic Drugs Against Cerebral Vasospasm after Subarachnoid Hemorrhage: A Comprehensive Review of Basic and Clinical Studies
Current Drug Delivery The Role of Nuclear Receptor PPARα in the Sleep-wake Cycle Modulation. A Tentative Approach for Treatment of Sleep Disorders
Current Drug Delivery Antibody-Based Therapies in Systemic Lupus Erythematosus
Mini-Reviews in Medicinal Chemistry Excess Exposure to Insulin Is the Primary Cause of Insulin Resistance and its Associated Atherosclerosis
Current Molecular Pharmacology Dermatologic Manifestations in the Antiphospholipid Syndrome
Current Rheumatology Reviews The Clinical Evaluation of Chronic Cough
Current Respiratory Medicine Reviews Editorial:
Current Immunology Reviews (Discontinued) The Influence of Different Disease States on Rituximab Pharmacokinetics
Current Drug Metabolism Immunopathology of Type 1 Diabetes and Immunomodulatory Effects of Stem Cells: A Narrative Review of the Literature
Endocrine, Metabolic & Immune Disorders - Drug Targets