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Current Drug Targets


ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Effects of Cissampelos sympodialis Eichl. and its Alkaloid, Warifteine, in an Experimental Model of Respiratory Allergy to Blomia tropicalis

Author(s): Ana Tereza Cerqueira-Lima, Neuza Maria Alcantara-Neves, Lain Carlos Pontes de Carvalho, Ryan Santos Costa, Jose Maria Barbosa-Filho, Marcia Piuvezam, Momtchilo Russo, Renato Barboza, Eduardo de Jesus Oliveira, Alexsandro Marinho and Camila Alexandrina Figueiredo

Volume 11, Issue 11, 2010

Page: [1458 - 1467] Pages: 10

DOI: 10.2174/1389450111009011458

Price: $65


Asthma is one of the most prevalent chronic diseases worldwide. Medicinal plants are historically used in its treatment. The plant Cissampelos sympodialis, known in Northeastern Brazil as “Jarrinha”or “Milona”, is used to treat some inflammatory conditions, including asthma. The objective of this study was to evaluate the potential of Cissampelos sympodialis EICHL. extract (CsE) and its isolated alkaloids, especially warifteine (Wa) on a Blomia tropicalis extract (BtE)-induced experimental model of allergy. The respiratory allergy was induced in AJ mice by the administration of BtE. Mice were orally treated with the 400 mg/kg of CsE or 8 mg/kg of total alkaloids fraction (TAF) or 4 mg/kg of Wa and the following parameters were analyzed: (a) total cell numbers in bronchoalveolar fluid (BAF); (b) differential cell numbers in BAF; (c) eosinophil peroxidase (EPO) activity in BAF; (d) IgE serum levels by passive cutaneous anaphylaxis; (e) IL-5, IL-13, IL-10, and IFN-γ levels in BAF; (f) histopathological alterations in the lung. The treatment of the animals with CsE, Wa or TAF led to a reduction in the numbers of total cells and eosinophils in BAF. The same reduction was observed in EPO levels in the BAF. The levels of IL-5 and IL-13 were also reduced in animals treated with Cissampelos sympodialis, while IL-10 levels were significantly increased in the BAF of CsE-treated animals. The treatment also decreased the density of inflammatory cells in the lung by histopathological examinations demonstrating the potential of this medicinal plant as new agent for asthma treatment.

Keywords: Asthma, Blomia tropicalis, Cissampelos sympodialis, natural products, warifteine, cytokines, tropicalis, sympodialis, natural, (CsE), (Wa), (TAF), (BAF), (EPO), IL-10, alkaloids, OVA, BtE, ELISA, (HPLC), EPO, (PCA), Bronchoalveolar Lavage Fluid, IFN-γ, Eosinophils, IgE, IgG4, NF-κB

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