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Current Alzheimer Research


ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Alzheimers Disease - An Interactive Perspective

Author(s): Klaus Heese and Hiroyasu Akatsu

Volume 3, Issue 2, 2006

Page: [109 - 121] Pages: 13

DOI: 10.2174/156720506776383022

Price: $65


Alzheimers disease (AD) is an age-related neurodegenerative disorder that is characterized by a progressive loss in memory and deterioration of the higher cognitive functions. The brain of an individual with AD exhibits extracellular senile plaques of aggregated amyloid-beta-peptide (Aβ), intracellular neurofibrillary tangles (NFTs) that consist of hyperphosphorylated tau protein (P-tau) and a profound loss of basal forebrain cholinergic neurons that innervate the hippocampus and the neocortex. Recent data obtained via genomics, proteomics and molecular genetics, have gleaned new information with regard to the physiological and pathophysiological functions of the amyloid precursor protein (APP) and its cleavage product Aβ. This review glances over several aspects that may play a major role in the pathogenesis of AD providing an insight into APPs and Aβs interplay with other cellular systems.

Keywords: Alzheimer's disease, apoptosis, cell death, neurodegeneration

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