Abstract
Hepatocellular carcinoma (HCC) is a leading cause of cancer related death both in the United States and worldwide. Proper management begins with identification of high risk individuals who may benefit from a screening program for HCC, since early detection of this cancer can lead to improved survival. Advances in radiographic technology and new staging systems that take tumor burden and clinical status into account allow patients to be more accurately stratified into proper treatment groups. Depending on the cancer stage, treatments such as radiofrequency ablation (RFA), surgical resection and liver transplantation offer a potential cure, while other treatments such as transarterial chemoembolization (TACE) can prolong life with HCC. New agents such as the oral multikinase inhibitor sorafenib show promise of slowing disease through utilization of molecular targeting. In this article, we will review management strategies of HCC, from diagnosis to treatment.
Keywords: Hepatocellular carcinoma, therapy, liver transplantation, diagnosis
Current Cancer Therapy Reviews
Title: Current Treatment Strategies for Hepatocellular Carcinoma
Volume: 6 Issue: 3
Author(s): Andrew Aronsohn and Smruti R. Mohanty
Affiliation:
Keywords: Hepatocellular carcinoma, therapy, liver transplantation, diagnosis
Abstract: Hepatocellular carcinoma (HCC) is a leading cause of cancer related death both in the United States and worldwide. Proper management begins with identification of high risk individuals who may benefit from a screening program for HCC, since early detection of this cancer can lead to improved survival. Advances in radiographic technology and new staging systems that take tumor burden and clinical status into account allow patients to be more accurately stratified into proper treatment groups. Depending on the cancer stage, treatments such as radiofrequency ablation (RFA), surgical resection and liver transplantation offer a potential cure, while other treatments such as transarterial chemoembolization (TACE) can prolong life with HCC. New agents such as the oral multikinase inhibitor sorafenib show promise of slowing disease through utilization of molecular targeting. In this article, we will review management strategies of HCC, from diagnosis to treatment.
Export Options
About this article
Cite this article as:
Aronsohn Andrew and R. Mohanty Smruti, Current Treatment Strategies for Hepatocellular Carcinoma, Current Cancer Therapy Reviews 2010; 6 (3) . https://dx.doi.org/10.2174/157339410791698151
DOI https://dx.doi.org/10.2174/157339410791698151 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Biomarkers in Systemic Sclerosis-Related Pulmonary Arterial Hypertension
Current Vascular Pharmacology Novel Therapeutic Approaches and Targets for the Treatment of Cardiovascular and Immunological Diseases
Current Pharmaceutical Biotechnology Gene Modified Cell Transplantation for Vascular Regeneration
Current Gene Therapy Secondary Metabolites in the Treatment of Diabetes Mellitus: A Paradigm Shift
Current Drug Metabolism From the Oxygen to the Organ Protection: Erythropoietin as Protagonist in Internal Medicine
Cardiovascular & Hematological Agents in Medicinal Chemistry Insulin Neuritis and Diabetic Cachectic Neuropathy: A Review
Current Diabetes Reviews Ponatinib: A Review of Efficacy and Safety
Current Cancer Drug Targets Membrane Transporters in Physiological Barriers of Pharmacological Importance
Current Pharmaceutical Design Cardiovascular Effects of Glucagon-Like Peptide 1
Mini-Reviews in Medicinal Chemistry Plasma Phospholipids are Associated with Mild Cognitive Impairment in Type 2 Diabetic Patients
Current Alzheimer Research Collagen Cross-link Breakers:A Beginning of a New Era in the Treatment of Cardiovascular Changes Associated with Aging,Diabetes,and Hypertension
Current Drug Targets - Cardiovascular & Hematological Disorders Mechanisms and Medical Management of Exercise Intolerance in Hypertrophic Cardiomyopathy
Current Pharmaceutical Design Mechanism of Cardiac Pathogenesis and Cardiotoxicity of Anti- COVID-19 Drugs
Coronaviruses Lithium and Kidney, 60 Years Later
Current Drug Safety Cutting through the Complexities of mTOR for the Treatment of Stroke
Current Neurovascular Research Alzheimer’s Disease and the Early Signs of Age-Related Macular Degeneration
Current Alzheimer Research Obstructive Sleep Apnea in Chronic Obstructive Pulmonary Disease: The Overlap Syndrome
Current Respiratory Medicine Reviews Hyperfibrinogenemia is Significantly Associated with an Increased Risk of In-hospital Mortality in Acute Ischemic Stroke Patients
Current Neurovascular Research Nanotechnology Advancements in the Diagnosis and Prevention of COVID-19: Past and Future
Coronaviruses Positive Airway Pressure in Sleep Disordered Breathing
Current Respiratory Medicine Reviews