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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

New Trends in Non-Aqueous Biocatalysis

Author(s): Hui-Lei Yu, Ling Ou and Jian-He Xu

Volume 14, Issue 14, 2010

Page: [1424 - 1432] Pages: 9

DOI: 10.2174/138527210791616740

Price: $65

Abstract

It is now well known that non-aqueous biocatalysis has emerged as an important area of systematic research and industrial development over the last two decades, fueled mainly by chemical and pharmaceutical interest. The non-aqueous biocatalysis boasts many potential advantages, including higher substrate solubility, reversal of hydrolytic reactions and modified enzyme specificity. As a consequence, applications of enzymatic catalysis in organic solvents range from chiral resolution of pharmaceuticals and their intermediates to enantio- or regio-selective synthesis of these substances. In this review, recent trends of biocatalyst engineering and solvent engineering in non-aqueous biocatalysis, diversified enzyme reactions for non-aqueous biocatalysis and a greener need for it have been discussed in detail with new examples.

Keywords: Non-aqueous biocatalysis, Biphasci reaction, Lipase, Reductase, Oxidizing enzyme, Ionic liquids, Green chemistry


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