Abstract
Molecular and cellular mechanisms of MDMA-induced toxicity have been extensively studied in a number of experimental models. Nevertheless, only few studies investigated the involvement of HSPs (“molecular chaperones”) in MDMA organs toxicity. In the present minireview we highlight this subject analysing the results of these studies conducted especially on brain tissue. Despite of it seems obvious that HSPs overexpression is a protective reaction against MDMA treatment, the molecular mechanisms for exerting their action are far to be undiscovered. At the same time, we need of comprehensive studies concerning the whole range of Hsps/chaperones expressions in all organs after acute and chronic administration of MDMA.
Keywords: 3,4-Methylenedioxy-N-methylamphetamine, brain toxicity, Hsp27, Hsp32, Hsp60, Hsp70
Current Pharmaceutical Biotechnology
Title: MDMA Administration and Heat Shock Proteins Response: Foreseeing a Molecular Link
Volume: 11 Issue: 5
Author(s): C. Pomara, S. D'Errico, L. Zummo, F. Cappello and G. Li Volti
Affiliation:
Keywords: 3,4-Methylenedioxy-N-methylamphetamine, brain toxicity, Hsp27, Hsp32, Hsp60, Hsp70
Abstract: Molecular and cellular mechanisms of MDMA-induced toxicity have been extensively studied in a number of experimental models. Nevertheless, only few studies investigated the involvement of HSPs (“molecular chaperones”) in MDMA organs toxicity. In the present minireview we highlight this subject analysing the results of these studies conducted especially on brain tissue. Despite of it seems obvious that HSPs overexpression is a protective reaction against MDMA treatment, the molecular mechanisms for exerting their action are far to be undiscovered. At the same time, we need of comprehensive studies concerning the whole range of Hsps/chaperones expressions in all organs after acute and chronic administration of MDMA.
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Pomara C., D'Errico S., Zummo L., Cappello F. and Li Volti G., MDMA Administration and Heat Shock Proteins Response: Foreseeing a Molecular Link, Current Pharmaceutical Biotechnology 2010; 11 (5) . https://dx.doi.org/10.2174/138920110791591445
DOI https://dx.doi.org/10.2174/138920110791591445 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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