Abstract
Squamous cell carcinoma of anal canal (SCCA) and its precursor lesions are increasing in prevalence for the diffusion of human papillomavirus infection. The treatment of the cancer of the anal canal represents a model for the application of organ sparing, combined modality therapy for curative treatment. Squamous cell carcinoma of anal canal was originally a surgically treated disease that required Abdominoperineal Resection (APR), approximately two thirds of patients are now cured with a combination of chemotherapy and radiation with sphincter preservation. This article reviews randomized trials and recent studies on chemoradiation for anal cancer.
Keywords: Anal cancer, radiotherapy, chemotherapy
Current Drug Therapy
Title: The Association of Chemotherapy and Radiotherapy in Squamous Cell Carcinoma of Anal Canal
Volume: 5 Issue: 3
Author(s): Francesca Valvo, Barbara Avuzzi and Federico Bozzetti
Affiliation:
Keywords: Anal cancer, radiotherapy, chemotherapy
Abstract: Squamous cell carcinoma of anal canal (SCCA) and its precursor lesions are increasing in prevalence for the diffusion of human papillomavirus infection. The treatment of the cancer of the anal canal represents a model for the application of organ sparing, combined modality therapy for curative treatment. Squamous cell carcinoma of anal canal was originally a surgically treated disease that required Abdominoperineal Resection (APR), approximately two thirds of patients are now cured with a combination of chemotherapy and radiation with sphincter preservation. This article reviews randomized trials and recent studies on chemoradiation for anal cancer.
Export Options
About this article
Cite this article as:
Valvo Francesca, Avuzzi Barbara and Bozzetti Federico, The Association of Chemotherapy and Radiotherapy in Squamous Cell Carcinoma of Anal Canal, Current Drug Therapy 2010; 5 (3) . https://dx.doi.org/10.2174/157488510791561093
DOI https://dx.doi.org/10.2174/157488510791561093 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
Call for Papers in Thematic Issues
Novel Therapeutic Approaches and Biomarkers for Chronic Kidney Disease (CKD)
The thematic issue on "Novel Therapeutic Approaches and Biomarkers for CKD" aims to provide a comprehensive exploration of cutting-edge strategies for the management of chronic kidney disease (CKD). This issue will delve into emerging therapeutic targets, focusing on critical aspects such as podocyte injury, endothelial dysfunction, and tubulointerstitial fibrosis, which ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Mass Spectrometry in the Elucidation of the Glycoproteome of Bacterial Pathogens
Current Proteomics Nanoparticles for the Treatment of Wounds
Current Pharmaceutical Design Molecular Pathology and Molecular Markers of Ductal Carcinoma in-situ
Current Cancer Therapy Reviews Probing the Phosphopeptide Specificities of Protein Tyrosine Phosphatases, SH2 and PTB Domains with Combinatorial Library Methods
Current Protein & Peptide Science Formulated Squalene for Food Related Applications
Recent Patents on Food, Nutrition & Agriculture Recent Progress in the Development of Quinoline Derivatives for the Exploitation of Anti-Cancer Agents
Anti-Cancer Agents in Medicinal Chemistry Recent Advances in QSAR and Their Applications in Predicting the Activities of Chemical Molecules, Peptides and Proteins for Drug Design
Current Protein & Peptide Science Rare Earth Doped Hydroxyapatite Nanoparticles for In Vitro Bioimaging Applications
Current Physical Chemistry Vascular and Cardiac Oxidative Stress and Inflammation as Targets for Cardioprotection
Current Pharmaceutical Design Pollutants in Organic Chemistry and Medicinal Chemistry Education Laboratory. Experimental and Machine Learning Studies
Current Topics in Medicinal Chemistry Exosome-like Nanoparticles: A New Type of Nanocarrier
Current Medicinal Chemistry Plasma Rich in Growth Factors Enhances Wound Healing and Protects from Photo-oxidative Stress in Dermal Fibroblasts and 3D Skin Models
Current Pharmaceutical Biotechnology Exploring Novel Immunological Interventions Using Immunoinfectomics
Anti-Infective Agents Lipid-Based Drug Delivery Systems for Cancer Treatment
Current Drug Targets Biological Nitration of Arachidonic Acid
Current Vascular Pharmacology Development of a New Combined Chemometrics Method, Applied in the Simultaneous Voltammetric Determination of Cinnamic Acid and 3, 4-Dihydroxy Benzoic Acid
Current Analytical Chemistry 18F-Containing Positron Emission Tomography Probe Conjugation Methodology for Biologics as Specific Binders for Tumors
Current Topics in Medicinal Chemistry Synthesis and Some Reactions of 1-aryl-4-acetyl-5-methyl-1,2,3-triazole Derivatives with Anticonvulsant Activity
Mini-Reviews in Medicinal Chemistry Patent Review of Novel Nanostructrued Devices, Nanofabrication Methods and Applications in Nanofluidics and Nanomedicine
Recent Patents on Nanotechnology Evaluation of Cytotoxic and Tyrosinase Inhibitory Activities of 2-phenoxy(thiomethyl) pyridotriazolopyrimidines: In Vitro and Molecular Docking Studies
Anti-Cancer Agents in Medicinal Chemistry