Abstract
Many different types of therapeutic genes, ranging from suicide genes, tumor suppressor genes, to genes encoding tumor-specific antigens, have been successfully delivered by insect baculoviral vectors to treat tumours in animal models. These encouraging results observed to date underscore the potential for using the non-human baculovirus to combat human cancer. The present review outlines the advances in this area and highlights the challenges behind translating the findings from research with baculoviral vectors into clinical practice.
Keywords: Baculovirus, viral vector, transduction, cancer therapy
Current Gene Therapy
Title: Potential Cancer Gene Therapy by Baculoviral Transduction
Volume: 10 Issue: 3
Author(s): Shu Wang and Ghayathri Balasundaram
Affiliation:
Keywords: Baculovirus, viral vector, transduction, cancer therapy
Abstract: Many different types of therapeutic genes, ranging from suicide genes, tumor suppressor genes, to genes encoding tumor-specific antigens, have been successfully delivered by insect baculoviral vectors to treat tumours in animal models. These encouraging results observed to date underscore the potential for using the non-human baculovirus to combat human cancer. The present review outlines the advances in this area and highlights the challenges behind translating the findings from research with baculoviral vectors into clinical practice.
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Wang Shu and Balasundaram Ghayathri, Potential Cancer Gene Therapy by Baculoviral Transduction, Current Gene Therapy 2010; 10 (3) . https://dx.doi.org/10.2174/156652310791321251
DOI https://dx.doi.org/10.2174/156652310791321251 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
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