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Current Molecular Medicine


ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Molecular Pathways Linking Inflammation and Cancer

Author(s): A. Mantovani

Volume 10, Issue 4, 2010

Page: [369 - 373] Pages: 5

DOI: 10.2174/156652410791316968

Price: $65


Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory component is present also in the microenvironment of tumours that are not epidemiologically related to inflammation. Compounds of the inflammatory tumour microenvironment include leukocytes, cytokines, complement components, and are orchestrated by transcription factors, such as NFkB and Stat3. Recent studies have begun to unravel molecular pathways linking inflammation and cancer. An intrinsic (driven by genetic events that cause neoplasia) and an extrinsic (driven by inflammatory conditions which predispose to cancer) pathway link inflammation and cancer. Smouldering inflammation in the tumour microenvironment promotes proliferation and survival of malignant cells, angiogenesis, metastasis, subversion of adaptive immunity, response to hormones and chemotherapeutic agents. Cancer-related inflammation represents a target for innovative diagnostic and therapeutic strategies.

Keywords: Inflammation, cancer, cytokines, chemokines, macrophages

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