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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

The Pauson-Khand Reaction in the Synthesis of Pharmacologically Active Compounds

Author(s): Jorg Habermann

Volume 14, Issue 11, 2010

Page: [1139 - 1152] Pages: 14

DOI: 10.2174/138527210791317085

Price: $65


The [2+2+1]-cycloaddition of an alkyne, an alkene and carbon monoxide known as Pauson-Khand reaction is a powerful way to install two new functional groups and a cycle into a molecule. The great potential of this reaction has thus far been underestimated in the synthesis of pharmacologically active compounds.

Keywords: Pauson-Khand reaction, drug discovery, Diversity-oriented synthesis, target-oriented synthesis

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