Abstract
Mono-aminergic neurotransmitters, in particular serotonin (5-HT), are involved in regulating a large number of psychological and physiological functions, and abnormal 5-HT transmission has been implicated in a wide variety of neuropsychiatric disorders. Positron emission tomography (PET) is a non-invasive nuclear imaging technique with exquisite sensitivity and specificity, allowing delineation of neurotransmitter function in vivo. Over the last two decades, PET has been used to investigate 5-HT function in several neuropsychiatric disorders, in particular mood and anxiety disorders, schizophrenia, Alzheimers disease, and impulse control disorders. In the present review, an overview of recent findings is provided, and possibilities for further research are discussed.
Keywords: Serotonin, positron emission tomography, depression, schizophrenia, Alzheimer, epilepsy
Current Pharmaceutical Design
Title: Investigating Serotonergic Function Using Positron Emission Tomography: Overview and Recent Findings
Volume: 16 Issue: 18
Author(s): D.J. Veltman, H.G. Ruhe and J. Booij
Affiliation:
Keywords: Serotonin, positron emission tomography, depression, schizophrenia, Alzheimer, epilepsy
Abstract: Mono-aminergic neurotransmitters, in particular serotonin (5-HT), are involved in regulating a large number of psychological and physiological functions, and abnormal 5-HT transmission has been implicated in a wide variety of neuropsychiatric disorders. Positron emission tomography (PET) is a non-invasive nuclear imaging technique with exquisite sensitivity and specificity, allowing delineation of neurotransmitter function in vivo. Over the last two decades, PET has been used to investigate 5-HT function in several neuropsychiatric disorders, in particular mood and anxiety disorders, schizophrenia, Alzheimers disease, and impulse control disorders. In the present review, an overview of recent findings is provided, and possibilities for further research are discussed.
Export Options
About this article
Cite this article as:
Veltman D.J., Ruhe H.G. and Booij J., Investigating Serotonergic Function Using Positron Emission Tomography: Overview and Recent Findings, Current Pharmaceutical Design 2010; 16 (18) . https://dx.doi.org/10.2174/138161210791293033
DOI https://dx.doi.org/10.2174/138161210791293033 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Immunotherapy Strategies for Spinal Cord Injury
Current Pharmaceutical Biotechnology Mobilization and Redistribution of Default Mode Network from Resting State to Task State in Amnestic Mild Cognitive Impairment
Current Alzheimer Research Anticonvulsants – Antidepressants Pharmacokinetic Drug Interactions: The Role of the CYP450 System in Psychopharmacology
Current Drug Metabolism Approaching Inherited Disease on a Genomic Scale
Current Genomics Anesthetics as Chemical Tools to Study the Structure and Function of Nicotinic Acetylcholine Receptors
Current Protein & Peptide Science Impact of Dietary Fats on Brain Functions
Current Neuropharmacology Tackling the Elusive Challenges Relevant to Conquering the 100-Plus Year Old Problem of Alzheimer’s Disease
Current Alzheimer Research The Influence of Vaccine on Febrile Seizure
Current Neuropharmacology Neurotransmitters and Chemokines Regulate Tumor Cell Migration: Potential for a New Pharmacological Approach to Inhibit Invasion and Metastasis Development
Current Pharmaceutical Design Establishing Genomic/Transcriptomic Links Between Alzheimer’s Disease and Type 2 Diabetes Mellitus by Meta-Analysis Approach
CNS & Neurological Disorders - Drug Targets The Infectious Etiology of Alzheimer’s Disease
Current Neuropharmacology Neurocysticercosis: The Enigmatic Disease
Central Nervous System Agents in Medicinal Chemistry Animal Mitochondria: Evolution, Function, and Disease
Current Molecular Medicine Cerebroprotective Functions of HO-2
Current Pharmaceutical Design Placental Drug Disposition and Its Clinical Implications
Current Drug Metabolism Applications and Synthesis of the Antiepileptic Drug Oxcarbazepine and Related Structures
Current Organic Chemistry Drug Treatment of Epilepsy: From Serendipitous Discovery to Evolutionary Mechanisms
Current Medicinal Chemistry Long-Term Outcome of Infants Born Late Preterm
Current Pediatric Reviews Triterpene Derivatives as Inhibitors of Protein Involved in the Inflammatory Process: Molecules Interfering with Phospholipase A2, Cycloxygenase, and Lipoxygenase
Current Drug Targets Central Sensitisation Phenomena in Primary Headaches: Overview of a Preventive Therapeutic Approach
CNS & Neurological Disorders - Drug Targets