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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Investigating Serotonergic Function Using Positron Emission Tomography: Overview and Recent Findings

Author(s): D.J. Veltman, H.G. Ruhe and J. Booij

Volume 16, Issue 18, 2010

Page: [1979 - 1989] Pages: 11

DOI: 10.2174/138161210791293033

Price: $65


Mono-aminergic neurotransmitters, in particular serotonin (5-HT), are involved in regulating a large number of psychological and physiological functions, and abnormal 5-HT transmission has been implicated in a wide variety of neuropsychiatric disorders. Positron emission tomography (PET) is a non-invasive nuclear imaging technique with exquisite sensitivity and specificity, allowing delineation of neurotransmitter function in vivo. Over the last two decades, PET has been used to investigate 5-HT function in several neuropsychiatric disorders, in particular mood and anxiety disorders, schizophrenia, Alzheimers disease, and impulse control disorders. In the present review, an overview of recent findings is provided, and possibilities for further research are discussed.

Keywords: Serotonin, positron emission tomography, depression, schizophrenia, Alzheimer, epilepsy

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