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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Natural Product-Inspired Synthesis of Thiazolidine and Thiazolidinone Compounds and their Anticancer Activities

Author(s): Qiu Zhang, Hongyu Zhou, Shumei Zhai and Bing Yan

Volume 16, Issue 16, 2010

Page: [1826 - 1842] Pages: 17

DOI: 10.2174/138161210791208983

Price: $65


Nature makes many pharmacologically active compounds containing thiazolidine and thiazolidinone scaffolds. These privileged structures have been identified in many random screening assays. Molecules containing these core structures have been designed and synthesized, and they show a broad range of anticancer activities in vitro and in vivo. The combinatorial library approach has been demonstrated to be effective in lead discovery and optimization in order to improve the potency and toxicity of these compounds.

Keywords: Thiazolidine, thiazolidinone, natural products, anticancer, combinatorial library approach

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