Abstract
Nature makes many pharmacologically active compounds containing thiazolidine and thiazolidinone scaffolds. These privileged structures have been identified in many random screening assays. Molecules containing these core structures have been designed and synthesized, and they show a broad range of anticancer activities in vitro and in vivo. The combinatorial library approach has been demonstrated to be effective in lead discovery and optimization in order to improve the potency and toxicity of these compounds.
Keywords: Thiazolidine, thiazolidinone, natural products, anticancer, combinatorial library approach
Current Pharmaceutical Design
Title: Natural Product-Inspired Synthesis of Thiazolidine and Thiazolidinone Compounds and their Anticancer Activities
Volume: 16 Issue: 16
Author(s): Qiu Zhang, Hongyu Zhou, Shumei Zhai and Bing Yan
Affiliation:
Keywords: Thiazolidine, thiazolidinone, natural products, anticancer, combinatorial library approach
Abstract: Nature makes many pharmacologically active compounds containing thiazolidine and thiazolidinone scaffolds. These privileged structures have been identified in many random screening assays. Molecules containing these core structures have been designed and synthesized, and they show a broad range of anticancer activities in vitro and in vivo. The combinatorial library approach has been demonstrated to be effective in lead discovery and optimization in order to improve the potency and toxicity of these compounds.
Export Options
About this article
Cite this article as:
Zhang Qiu, Zhou Hongyu, Zhai Shumei and Yan Bing, Natural Product-Inspired Synthesis of Thiazolidine and Thiazolidinone Compounds and their Anticancer Activities, Current Pharmaceutical Design 2010; 16 (16) . https://dx.doi.org/10.2174/138161210791208983
DOI https://dx.doi.org/10.2174/138161210791208983 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cerebrovascular Complications of Diabetes: SGLT-2 Inhibitors as a Promising Future Therapeutics
Current Drug Targets Metallodrugs in Targeted Cancer Therapeutics: Aiming at Chemoresistance- related Patterns and Immunosuppressive Tumor Networks
Current Medicinal Chemistry Phytotherapeutic Agents for Benign Prostatic Hyperplasia: An Overview
Mini-Reviews in Medicinal Chemistry Molecular Aspects of FKBP51 that Enable Melanoma Dissemination
Current Molecular Pharmacology Transforming Growth Factor-β Signaling in Motor Neuron Diseases
Current Molecular Medicine Peptides Targeting Angiogenesis Related Growth Factor Receptors
Current Pharmaceutical Design ONCOFID™-P a Hyaluronic Acid Paclitaxel Conjugate for the Treatment of Refractory Bladder Cancer and Peritoneal Carcinosis
Current Bioactive Compounds The Neurokinins: Peptidomimetic Ligand Design and Therapeutic Applications
Current Medicinal Chemistry Circulating microRNAs as Potential Diagnostic, Prognostic and Therapeutic Targets in Pancreatic Cancer
Current Pharmaceutical Design Endocannabinoids as Regulators of Transient Receptor Potential (TRP)Channels: a Further Opportunity to Develop New Endocannabinoid-Based Therapeutic Drugs
Current Medicinal Chemistry Long-term Exposure to Cadmium in Food and Cigarette Smoke, Liver Effects and Hepatocellular Carcinoma
Current Drug Metabolism Insulin Management for Type 1 Diabetic Patients During Social Alcohol Consumption: The SPRITZ Study
Current Diabetes Reviews Targeting of Low-Molecular Weight Drugs to Mammalian Mitochondria
Drug Design Reviews - Online (Discontinued) Application of Nanotechnology in the Treatment and Diagnosis of Gastrointestinal Cancers: Review of Recent Patents
Recent Patents on Anti-Cancer Drug Discovery Is Brain-Derived Neurotrophic Factor: A Common Link Between Neurodegenerative Disorders and Cancer?
Current Alzheimer Research Screening for Infectious Diseases During Pregnancy: Which Test and Which Situation
Current Women`s Health Reviews Photodynamic Therapy For Non-Melanoma Skin Cancers
Current Cancer Therapy Reviews Involvement of Membrane Channels in Autoimmune Disorders
Current Pharmaceutical Design Regulation of the Endoplasmic Reticulum Ca2+-Store in Cancer
Anti-Cancer Agents in Medicinal Chemistry Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation
Current Molecular Medicine