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Current Drug Therapy


ISSN (Print): 1574-8855
ISSN (Online): 2212-3903

A Guide to Treatment of Sarcoidosis

Author(s): Ilias C. Papanikolaou, Hidenobu Shigemitsu and Om P. Sharma

Volume 5, Issue 2, 2010

Page: [122 - 131] Pages: 10

DOI: 10.2174/157488510791065102

Price: $65


Not all sarcoidosis patients need treatment. In about 40% of cases, disease will subside spontaneously. For the rest who need to be treated, older drugs like corticosteroids, methotrexate and hydroxychloroquine, as well as the more recent anti-TNF agents, will be effective in suppressing granulomatous inflammation in every organ involved in about 30% of cases. In 20% of the patients, disease will relapse upon discontinuation or tapering of treatment, and in 10% will progress (these two categories constituting chronic disease). In these cases, reinstitution of the same or alternative medication or a combination regimen is warranted. Drugs side-effects and patients comorbidities should be taken in consideration during the selection of the appropriate regimen.

Keywords: Sarcoidosis, treatment, corticosteroids, methotrexate, hydroxychloroquine, infliximab

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