Nanoparticles for Tumor Targeted Therapies and Their Pharmacokinetics

Title: Nanoparticles for Tumor Targeted Therapies and Their Pharmacokinetics

Volume: 11 Issue: 2

Author(s): Jianqiu Wang, Meihua Sui and Weimin Fan

Affiliation:

Keywords: Nanoparticles, tumor targeting, release, pharmacokinetics, safety

Abstract: Various types of nanoparticles, such as liposomes, polymeric micelles, dendrimers, superparamagnetic iron oxide crystals, and colloidal gold, have been employed in targeted therapies for cancer. Both passive and active targeting strategies can be utilized for nanodrug delivery. Passive targeting is based on the enhanced permeability and retention (EPR) effect of the vasculature surrounding tumors. Active targeting relies on ligand-directed binding of nanoparticles to receptors expressed by tumor cells. Release of loaded drugs from nanoparticles may be controlled in response to changes in environmental condition such as temperature and pH. Biodistribution profiles and anticancer efficacy of nano-drugs in vivo would be different depending upon their size, surface charge, PEGylation and other biophysical properties. This review focuses on the recent development of nanoparticles for tumor targeted therapies, including physicochemical properties, tumor targeting, control of drug release, pharmacokinetics, anticancer efficacy and safety. Future perspectives are discussed as well.

Cite this article as:

Wang Jianqiu, Sui Meihua and Fan Weimin, Nanoparticles for Tumor Targeted Therapies and Their Pharmacokinetics, Current Drug Metabolism 2010; 11 (2) . https://dx.doi.org/10.2174/138920010791110827