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Current Gene Therapy


ISSN (Print): 1566-5232
ISSN (Online): 1875-5631

Lactococcus lactis as a Cell Factory for Delivery of Therapeutic Proteins

Author(s): Mohammed Bahey-El-Din, Cormac G.M. Gahan and Brendan T. Griffin

Volume 10, Issue 1, 2010

Page: [34 - 45] Pages: 12

DOI: 10.2174/156652310790945557

Price: $65


The food-grade bacterium Lactococcus lactis has been extensively investigated during the last two decades as a delivery vector for therapeutic proteins, DNA and vaccine antigens. The bacterium represents a safe, genetically tractable vector capable of producing heterologous therapeutic proteins at mucosal sites. Here we review recent work in which recombinant L. lactis strains have been exploited as agents to treat inflammatory bowel disease, allergy and cancer. We also describe the ability of L. lactis to deliver proteins with adjuvant potential, vaccines and DNA and discuss the therapeutic possibilities of this approach.

Keywords: Lactococcus, vaccine, therapeutic protein, vector, delivery, immunomodulation, IBD

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