siRNA Delivery Using Nanocarriers – An Efficient Tool for Gene Silencing

Title: siRNA Delivery Using Nanocarriers – An Efficient Tool for Gene Silencing

Volume: 10 Issue: 2

Author(s): Bharat Khurana, Amit K. Goyal, Abhishek Budhiraja, Daisy Arora and Suresh P. Vyas

Affiliation:

Keywords: siRNA, Gene Silencing, viral vector, non-viral vector, polymeric systems

Abstract: Small interfering RNAs (siRNA) are one of the most recent additions used to silence gene expression. At present, siRNA is the most extensively used gene-silencing technique over other nucleic-acid based approaches to treat diseases including cancer, hepatitis, respiratory disease, cardiovascular diseases, neuronal disease and autoimmune disease. However, systemic delivery of siRNA remains to be the biggest challenge to be overcome. Various strategies have been developed to deliver siRNA efficiently into target cell such as chemical modification of siRNA, physical strategies, viral and non viral-vectors mediated delivery. Among all the approaches non viral vectors including lipoplexes, polyplexes and inorganic nanoparticles were found to be most successful which have been reviewed in this article. Further therapeutic applications of RNAi have also been briefly reviewed.

Cite this article as:

Khurana Bharat, K. Goyal Amit, Budhiraja Abhishek, Arora Daisy and P. Vyas Suresh, siRNA Delivery Using Nanocarriers – An Efficient Tool for Gene Silencing, Current Gene Therapy 2010; 10 (2) . https://dx.doi.org/10.2174/156652310791111010