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Current Neuropharmacology


ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

General Anesthetic Actions on GABAA Receptors

Author(s): Paul S. Garcia, Scott E. Kolesky and Andrew Jenkins

Volume 8 , Issue 1 , 2010

Page: [2 - 9] Pages: 8

DOI: 10.2174/157015910790909502

Price: $65


General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these interactions are critical for producing anesthesia. Over the last 20 years, neuropharmacologists have revealed that one of the most important target sites for general anesthetics is the GABAA receptor. In this review we will discuss what is known about anesthetic – GABAA receptor interactions.

Keywords: GABAA Receptor, General Anesthetic, Isoflurane, Desflurane, Sevoflurane, Propofol, Etomidate, Barbiturates

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