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Current Pharmaceutical Biotechnology


ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Development of an Artificial Chaperone System Based on Cyclodextrin

Author(s): Yoshihiro Sasaki and Kazunari Akiyoshi

Volume 11, Issue 3, 2010

Page: [300 - 305] Pages: 6

DOI: 10.2174/138920110791111951

Price: $65


Molecular chaperones in living systems inspired us to explore new concepts for assisting protein refolding. The chaperone selectively interacts with a non-native protein by hydrophobic interaction to prevent irreversible aggregation and releases the protein in its refolded form with the aid of ATP and another co-chaperone. Cyclodextrins have been used to simulate the function of the chaperones by controlling the hydrophobic interaction with proteins. In this chapter, we review the cyclodextrin (CD)-related protein refolding systems.

Keywords: Cyclodextrin, artificial chaperone, surfactant, nanogel, hydrophobized polymer

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