Abstract
Aryl amines and ethers are very important structural motifs of numerous biologically active natural products, important pharmaceutical compounds, polymers in the material science industries and widely used as drugs, dyes, and other fine chemicals. Several studies have earlier been attempted but transition metal mediated protocols have proven more successful results. Conventional Ullmann condensation with copper in the form of metal, alloy or Cu(I)/Cu(II) salt showed major drawbacks such as requirement of high temperature sensitivity to catalyst-type and low to moderate yield. In recent years, copper promoted conventional Ullmann condensation reactions have been improved a lot under ligand and ligand free conditions with excellent conversion. An important Ullmann type coupling, where aryl boronic acids are used as arylating agents instead of aryl halides has recently attracted much attention of chemist. Because of the importance of aryl amines and ethers in various fields of chemistry writing a review in this relevant area is of significant interest. This article will review the applications of copper-promoted C-N and C-O bond formation reactions focused on achievements during the periods from 2000-2008.
Current Organic Chemistry
Title: Copper Promoted C-N and C-O Type Cross-Coupling Reactions
Volume: 14 Issue: 8
Author(s): Pralay Das, Dharminder Sharma, Manish Kumar and Bikram Singh
Affiliation:
Abstract: Aryl amines and ethers are very important structural motifs of numerous biologically active natural products, important pharmaceutical compounds, polymers in the material science industries and widely used as drugs, dyes, and other fine chemicals. Several studies have earlier been attempted but transition metal mediated protocols have proven more successful results. Conventional Ullmann condensation with copper in the form of metal, alloy or Cu(I)/Cu(II) salt showed major drawbacks such as requirement of high temperature sensitivity to catalyst-type and low to moderate yield. In recent years, copper promoted conventional Ullmann condensation reactions have been improved a lot under ligand and ligand free conditions with excellent conversion. An important Ullmann type coupling, where aryl boronic acids are used as arylating agents instead of aryl halides has recently attracted much attention of chemist. Because of the importance of aryl amines and ethers in various fields of chemistry writing a review in this relevant area is of significant interest. This article will review the applications of copper-promoted C-N and C-O bond formation reactions focused on achievements during the periods from 2000-2008.
Export Options
About this article
Cite this article as:
Das Pralay, Sharma Dharminder, Kumar Manish and Singh Bikram, Copper Promoted C-N and C-O Type Cross-Coupling Reactions, Current Organic Chemistry 2010; 14 (8) . https://dx.doi.org/10.2174/138527210791111830
DOI https://dx.doi.org/10.2174/138527210791111830 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Seasonal Allergic Rhinitis
Recent Patents on Inflammation & Allergy Drug Discovery Diversity in Medicinal Chemistry Space
Current Topics in Medicinal Chemistry Epidemiology of Vitamin D and Colorectal Cancer
Anti-Cancer Agents in Medicinal Chemistry Hydroxysteroid Dehydrogenase (17β -HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors:Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Does SARS-CoV-2 Affect Male Urogenital System?
Current Pharmaceutical Biotechnology Multi-Shift Single-Vehicle Routing Problem Under Fuzzy Uncertainty During the COVID-19 Pandemic
Journal of Fuzzy Logic and Modeling in Engineering Prevalence of COVID-19-like Symptoms among People Living with HIV, and Using Antiretroviral Therapy for Prevention and Treatment
Current HIV Research Suramin: Clinical Uses and Structure-Activity Relationships
Mini-Reviews in Medicinal Chemistry An Overview of Partial Synthesis and Transformations of Secosteroids
Current Organic Chemistry STAT 3 as a Target for Cancer Drug Discovery
Current Medicinal Chemistry Discovery of a “Cocktail” of Potential SARS-COV-2 Main Protease Inhibitors through Virtual Screening of Known Chemical Components of Vitex negundo L. (“Lagundi”)
Medicinal Chemistry Current Progress in Natural Product-like Libraries for Discovery Screening
Combinatorial Chemistry & High Throughput Screening Recent Development of Peptide Drugs and Advance on Theory and Methodology of Peptide Inhibitor Design
Medicinal Chemistry Anti-Malarial
Current Bioactive Compounds Mitochondria as a Therapeutic Target in Alzheimers Disease and Diabetes
CNS & Neurological Disorders - Drug Targets Computational Intelligence Methods for Docking Scores
Current Computer-Aided Drug Design Signal Transduction Pathways and Transcription Factors as Therapeutic Targets in Inflammatory Disease: Towards Innovative Antirheumatic Therapy
Current Pharmaceutical Design Photocatalytic Inactivation of Bioaerosols: A Short Review on Emerging Technologies
Current Analytical Chemistry Sense of Smell: Structural, Functional, Mechanistic Advancements and Challenges in Human Olfactory Research
Current Neuropharmacology Fibroblast Growth Factor Receptor Inhibitors
Current Pharmaceutical Design