Abstract
In recent years, phosphonic acids and their derivatives have received increasing attention as analogues of a series of naturally occurring phosphates and as “bio-isosteric phosphorus analogues” of aminoacids. Unlike a phosphate group, the phosphonate moiety is not readily hydrolyzed, in a biological environment, by the enzymes involved in the phosphate cleavage. This feature makes these compounds extremely useful in several applications, in metabolic regulation, in enhancement or inhibition studies, in the development of potential drugs against several metabolic disorders. The great potential of these compounds in biological applications resulted in an intense effort directed to the development of efficient synthetic methods for their preparation, with particular attention to stereoselective synthesis. The purpose of this review is to give an up-to-date account of the chemistry, the synthesis and the biological activity of aminophosphonic acids and their derivatives.
Keywords: Aminophosphonic acids, Aminophosphonates, Synthesis, Asymmetric synthesis, Biological activity
Current Medicinal Chemistry
Title: Aminophosphonic Acids and Derivatives. Synthesis and Biological Applications
Volume: 17 Issue: 3
Author(s): F. Orsini, G. Sello and M. Sisti
Affiliation:
Keywords: Aminophosphonic acids, Aminophosphonates, Synthesis, Asymmetric synthesis, Biological activity
Abstract: In recent years, phosphonic acids and their derivatives have received increasing attention as analogues of a series of naturally occurring phosphates and as “bio-isosteric phosphorus analogues” of aminoacids. Unlike a phosphate group, the phosphonate moiety is not readily hydrolyzed, in a biological environment, by the enzymes involved in the phosphate cleavage. This feature makes these compounds extremely useful in several applications, in metabolic regulation, in enhancement or inhibition studies, in the development of potential drugs against several metabolic disorders. The great potential of these compounds in biological applications resulted in an intense effort directed to the development of efficient synthetic methods for their preparation, with particular attention to stereoselective synthesis. The purpose of this review is to give an up-to-date account of the chemistry, the synthesis and the biological activity of aminophosphonic acids and their derivatives.
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Cite this article as:
Orsini F., Sello G. and Sisti M., Aminophosphonic Acids and Derivatives. Synthesis and Biological Applications, Current Medicinal Chemistry 2010; 17 (3) . https://dx.doi.org/10.2174/092986710790149729
DOI https://dx.doi.org/10.2174/092986710790149729 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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