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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Recent Advances in Catalytic Enantioselective Fluorination of Active Methines

Author(s): Young Ku Kang and Dae Young Kim

Volume 14, Issue 9, 2010

Page: [917 - 927] Pages: 11

DOI: 10.2174/138527210791111768

Price: $65


Organofluorine compounds are central importance in the pharmaceutical and agrochemical industries because the replacement of a hydrogen with a fluorine atom in biologically active molecules can be beneficial in terms of physicochemical properties and biological activities. Thus, the development of effective methodologies for the preparation of chiral organic fluorine compounds through C-F bond formation is still a highly desirable goal in synthetic organic chemistry. In this account, we review latest progresses in the area of catalytic enantioselective electrophilic fluorination of active methine compounds.

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