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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Distinctive Cellular Roles for Novel Protein Kinase C Isoenzymes

Author(s): G. Perletti and D. M. Terrian

Volume 12, Issue 24, 2006

Page: [3117 - 3133] Pages: 17

DOI: 10.2174/138161206777947498

Price: $65


A number of in vitro studies have implicated protein kinase Cδ(PKCδ) and PKCε in the regulation of the immune system. In recent years, this has been convincingly demonstrated in mice deficient for PKCδ and PKCε. The reported phenotypes for these transgenic mice indicate that PKCδ suppresses immunoresponsiveness and inhibits the proliferation of B-lymphocytes, while PKCε is required for macrophages to mount an effective immune response to bacterial pathogens. In either case, these isoenzymes appear to cooperate in fine-tuning certain immunoreactions by either suppressing (PKCδ) or stimulating (PKCε) the transcription of various cytokines. This review will compare and contrast the structures of these two nPKC isoenzymes and their respective roles in the modulation of cytokine production and various other cellular processes, such as growth, differentiation, apoptosis, and tumor suppression.

Keywords: Protein kinase C, PKC, isoenzymes, PKC epsilon, PKC delta

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