Abstract
Ethyl-4-thienyl-6-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine carboxyl ate (4) was obtained by the reaction of thiophene-2-carbaldehyde, urea and ethylbenzoylacetate. Reaction of (4) with phosphorous oxy chloride followed by hydrazine hydrate afforded the hydrazide (6), condensation of (6) with D-glucose followed by acetylation gave the acetylated compound (8), which cyclized into triazolopyrimidine derivatives (9) in presence of bromine/acetic acid the deprotection of compound (9) in presence of TEA/MeOH afforded the deprotected compound (10). Selected members of the compounds were screened for antimicrobial activity.
Current Organic Chemistry
Title: Synthesis of Tetrahydropyrimidine Derivatives and its Glycosides
Volume: 13 Issue: 18
Author(s): Wesam S. Shehab
Affiliation:
Abstract: Ethyl-4-thienyl-6-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine carboxyl ate (4) was obtained by the reaction of thiophene-2-carbaldehyde, urea and ethylbenzoylacetate. Reaction of (4) with phosphorous oxy chloride followed by hydrazine hydrate afforded the hydrazide (6), condensation of (6) with D-glucose followed by acetylation gave the acetylated compound (8), which cyclized into triazolopyrimidine derivatives (9) in presence of bromine/acetic acid the deprotection of compound (9) in presence of TEA/MeOH afforded the deprotected compound (10). Selected members of the compounds were screened for antimicrobial activity.
Export Options
About this article
Cite this article as:
Shehab S. Wesam, Synthesis of Tetrahydropyrimidine Derivatives and its Glycosides, Current Organic Chemistry 2009; 13 (18) . https://dx.doi.org/10.2174/138527209789630451
DOI https://dx.doi.org/10.2174/138527209789630451 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements