Abstract
Rho-kinase (ROCK) is one of the effectors of the small GTP-binding protein Rho. Accumulating evidence suggests that the Rho/ROCK system may play an important role in the pathogenesis of atherosclerosis and coronary vasospasm via its action in vascular smooth muscle cell contraction, endothelial function and the inflammatory process. Recent observations suggest that the beneficial cardiovascular effects of statins may, at least in part, derive from the inhibition of ROCKs. Fasudil is a ROCKs inhibitor which has potential benefits in coronary artery spasm and myocardial ischemia. In this review, we aim to describe the current understanding of ROCKs signaling and their roles in the pathophysiology of atherosclerosis and coronary spasm.
Keywords: Rho-kinase (ROCK), inhibitor, atheroscleorosis, kallikrein inhibitors, coronary spasm
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title: Current Status of Rho-Associated Kinases (ROCKs) in Coronary Atherosclerosis and Vasospasm
Volume: 7 Issue: 4
Author(s): Ming Dong, Bryan P. Yan and Chuek-Man Yu
Affiliation:
Keywords: Rho-kinase (ROCK), inhibitor, atheroscleorosis, kallikrein inhibitors, coronary spasm
Abstract: Rho-kinase (ROCK) is one of the effectors of the small GTP-binding protein Rho. Accumulating evidence suggests that the Rho/ROCK system may play an important role in the pathogenesis of atherosclerosis and coronary vasospasm via its action in vascular smooth muscle cell contraction, endothelial function and the inflammatory process. Recent observations suggest that the beneficial cardiovascular effects of statins may, at least in part, derive from the inhibition of ROCKs. Fasudil is a ROCKs inhibitor which has potential benefits in coronary artery spasm and myocardial ischemia. In this review, we aim to describe the current understanding of ROCKs signaling and their roles in the pathophysiology of atherosclerosis and coronary spasm.
Export Options
About this article
Cite this article as:
Dong Ming, Yan P. Bryan and Yu Chuek-Man, Current Status of Rho-Associated Kinases (ROCKs) in Coronary Atherosclerosis and Vasospasm, Cardiovascular & Hematological Agents in Medicinal Chemistry 2009; 7 (4) . https://dx.doi.org/10.2174/187152509789541891
DOI https://dx.doi.org/10.2174/187152509789541891 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
Call for Papers in Thematic Issues
Medicinal Plants with Beneficial Properties on Diabetes and Hypertension
Diabetes and hypertension are real scourges of the 21st century. It is imperative to act in order to find innovative solutions to this problem. Taking medications such as hypoglycemic and antihypertensive drugs may aggravate certain underlying comorbidities, such as chronic kidney disease and cardiovascular disease. This significant drawback therefore requires ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Antiplatelet and Antithrombotic Actions of Statins
Current Pharmaceutical Design Cytochrome P450s: Mechanisms and Biological Implications in Drug Metabolism and its Interaction with Oxidative Stress
Current Drug Metabolism The Role of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase Signaling in Cardiovascular Therapy
Current Signal Transduction Therapy Diabetic Cardiovascular Disease – AMP-Activated Protein Kinase (AMPK) as a Therapeutic Target
Cardiovascular & Hematological Agents in Medicinal Chemistry Application of VEGF Gene Therapy in Two Basic Fields of Plastic- Reparative Surgery: Tissue Reconstruction with Flaps and Peripheral Nerve Surgery
Recent Patents on Regenerative Medicine Efficacy and Cardiovascular Safety of Sulfonylureas
Current Drug Safety Cardiovascular Biology of Interleukin-6
Current Pharmaceutical Design Cardiovascular Disease and Inflammation: Novel Biomarkers of Inflammation and Endothelial Activation
Vascular Disease Prevention (Discontinued) Inflammatory Cytokines, Growth Factors, and Depression
Current Pharmaceutical Design Vascular Progenitor Cells in the Development of Transplant Arteriopathy
Current Genomics Ceramidases in Hematological Malignancies: Senseless or Neglected Target?
Anti-Cancer Agents in Medicinal Chemistry Potential Therapeutic Effects of Oleuropein Aglycone in Alzheimer's Disease
Current Pharmaceutical Biotechnology A Mini Review on the Chemistry and Neuroprotective Effects of Silymarin
Current Drug Targets The role of NADPH Oxidase in Vascular Disease – Hypertension, Atherosclerosis & Stroke
Current Pharmaceutical Design Recent Developments in Pharmacologic Prophylaxis of Atrial Fibrillation in Patients Undergoing Surgical Revascularization
Cardiovascular & Hematological Agents in Medicinal Chemistry The Pleiotropic Effects of PPARs on Vascular Cells and Angiogenesis: Implications for Tissue Engineering
Current Stem Cell Research & Therapy Pulmonary Hypertension: Current Therapy and Future Prospects
Cardiovascular & Hematological Agents in Medicinal Chemistry Endothelin-Converting Enzyme Inhibitors
Current Enzyme Inhibition Beneficial Effects of the Mediterranean Diet on Metabolic Syndrome
Current Pharmaceutical Design Potential of Resveratrol in Preventing the Development of Heart Failure
Current Chemical Biology