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Current Genomics


ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Mechanisms and Signals for the Nuclear Import of Proteins

Author(s): Natalia Freitas and Celso Cunha

Volume 10, Issue 8, 2009

Page: [550 - 557] Pages: 8

DOI: 10.2174/138920209789503941

Price: $65


In eukaryotes, the nuclear membrane provides a physical barrier to the passive diffusion of macromolecules from and into the cytoplasm. Nucleocytoplasmic traffic occurs through highly specialized structures known as nuclear pores, and involves the participation of a special class of transport proteins. Active transport across the nuclear pores is an energy-dependent process that relies on the activity of Ran-GTPases both in the nuclear and cytoplasmic compartments. Nuclear import of proteins is an essential step in regulating gene expression and the replication cycle of several viruses. In this review, the key mechanisms, pathways, and models underlying the transport of proteins across nuclear pores are analysed.

Keywords: Nuclear pore complex, nuclear localization signal, importin, nuclear transport

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