Generic placeholder image

Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Systemic Sclerosis at the Cellular Level: Molecular Pathways of Pathogenesis and its Implication on Future Drug Design

Author(s): S. W. Schulz and C. T. Derk

Volume 16, Issue 30, 2009

Page: [3986 - 3995] Pages: 10

DOI: 10.2174/092986709789352259

Price: $65


Endothelial cell abnormalities and the effects on the surrounding microvasculature is a focal point in the pathogenesis of Systemic Sclerosis disease and may even be the sentinel event for the initiation of this disorder. A better understanding of these processes may improve our understanding of the pathophysiology of Systemic Sclerosis and more specifically the vasculopathy observed. Such knowledge will help us to further current treatments options and design novel therapies for Systemic Sclerosis and other fibrotic disorders.

Keywords: Scleroderma, systemic sclerosis, fibrosis, vasculopathy, Raynaud's, pathogenesis

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy