Abstract
Over the last decade a wealth of studies have shed new light on the role of aldosterone in the pathogenesis of cardiovascular diseases. It is now evident that in addition to its classical role in increasing sodium reabsorbtion in the kidney , aldosterone also exhibits several nonepithelial effects such as the induction of inflammation, fibrosis and necrosis in various organs. Herein we review the experimental evidences for the protective effects of mineralocorticoid receptor blockade in the prevention and treatment of target organ damage, both in animals and in humans. We also discuss the pharmacological and clinical differences between the two available mineralocorticoid receptor blockers, spironolactone and eplerenone.
Keywords: Aldosterone, eplerenone, spironolactone, mineralocorticoid receptor, mineralocorticoid receptor antagonists
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title: Mineralocorticoid Receptor Blockade in the Protection of Target Organ Damage
Volume: 4 Issue: 1
Author(s): Paolo Mulatero, Alberto Milan, Tracy A. Williams and Franco Veglio
Affiliation:
Keywords: Aldosterone, eplerenone, spironolactone, mineralocorticoid receptor, mineralocorticoid receptor antagonists
Abstract: Over the last decade a wealth of studies have shed new light on the role of aldosterone in the pathogenesis of cardiovascular diseases. It is now evident that in addition to its classical role in increasing sodium reabsorbtion in the kidney , aldosterone also exhibits several nonepithelial effects such as the induction of inflammation, fibrosis and necrosis in various organs. Herein we review the experimental evidences for the protective effects of mineralocorticoid receptor blockade in the prevention and treatment of target organ damage, both in animals and in humans. We also discuss the pharmacological and clinical differences between the two available mineralocorticoid receptor blockers, spironolactone and eplerenone.
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Cite this article as:
Mulatero Paolo, Milan Alberto, Williams A. Tracy and Veglio Franco, Mineralocorticoid Receptor Blockade in the Protection of Target Organ Damage, Cardiovascular & Hematological Agents in Medicinal Chemistry 2006; 4 (1) . https://dx.doi.org/10.2174/187152506775268776
DOI https://dx.doi.org/10.2174/187152506775268776 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
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