Abstract
Introduction: HIV-1 is regarded most responsible for a neurodegenerative disease, called HIV-associated dementia (HAD). The pathogenic trait of this severe complication of HIV-infection is still unclear, but disturbed systemic and central nervous system immune function seem to be an important component. Cytokines are important mediators of the human immune system. The review focusses on major cytokines and related immune modulators. Methods: For literature research, the PubMed library, Ovid, Cochrane database, Scirus and Google scholar were used. Results: The article discusses the importance of interferons, interleukins, chemokines, adhesion molecules, colony stimulating factors and tumor necrosis factors. Conclusion: The role of cytokines in the development to HAD is still not clear. Neither their diagnostical or therapeutical potentials nor the basic pathogenetic involvements are completely understood, but the importance of those molecules is evident.
Keywords: HIV, CNS, cytokines, interleukins, chemokines, TNF, HAD, adhesion molecules
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Cytokines in HIV-Infection - Inflammatory Damage or Therapeutic Potential?
Volume: 8 Issue: 2
Author(s): Gabriele Arendt and Thorsten Nolting
Affiliation:
Keywords: HIV, CNS, cytokines, interleukins, chemokines, TNF, HAD, adhesion molecules
Abstract: Introduction: HIV-1 is regarded most responsible for a neurodegenerative disease, called HIV-associated dementia (HAD). The pathogenic trait of this severe complication of HIV-infection is still unclear, but disturbed systemic and central nervous system immune function seem to be an important component. Cytokines are important mediators of the human immune system. The review focusses on major cytokines and related immune modulators. Methods: For literature research, the PubMed library, Ovid, Cochrane database, Scirus and Google scholar were used. Results: The article discusses the importance of interferons, interleukins, chemokines, adhesion molecules, colony stimulating factors and tumor necrosis factors. Conclusion: The role of cytokines in the development to HAD is still not clear. Neither their diagnostical or therapeutical potentials nor the basic pathogenetic involvements are completely understood, but the importance of those molecules is evident.
Export Options
About this article
Cite this article as:
Arendt Gabriele and Nolting Thorsten, Cytokines in HIV-Infection - Inflammatory Damage or Therapeutic Potential?, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2009; 8 (2) . https://dx.doi.org/10.2174/187152309789152066
DOI https://dx.doi.org/10.2174/187152309789152066 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Editorial [ NeuroAIDS: A Neuroscience Problem with Global Impact ]
Current HIV Research Antioxidant Activity of Galantamine and Some of its Derivatives
Current Medicinal Chemistry An Efficient Ionic Liquid Mediated Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Piperidone Embedded α ,β-Unsaturated Ketones
Medicinal Chemistry Inflammation in the CNS: Understanding Various Aspects of the Pathogenesis of Alzheimer's Disease
Current Alzheimer Research Automatic Assessment of Cognitive Tests for Differentiating Mild Cognitive Impairment: A Proof of Concept Study of the Digit Span Task
Current Alzheimer Research The Role of Neurogenesis in Neurodegenerative Diseases and its Implications for Therapeutic Development
CNS & Neurological Disorders - Drug Targets Stroke History is an Independent Risk Factor for Poor Prognosis in Ischemic Stroke Patients: Results from a Large Nationwide Stroke Registry
Current Neurovascular Research Decreasing Arterial Aging by Controlling Blood Pressure Levels and Hypertension: A Step Forward
Current Vascular Pharmacology Structural Diversity of Neuritogenic Substances and their Application Perspective
Mini-Reviews in Medicinal Chemistry Enhancing the Delivery of Anti Retroviral Drug “Saquinavir” Across the Blood Brain Barrier Using Nanoparticles
Current HIV Research Natural Non-Trasgenic Animal Models for Research in Alzheimers Disease
Current Alzheimer Research Subcutaneous Immunoglobulins: A Promising Alternative for Immunomodulation?
Current Pharmaceutical Design Getting an Insight into the Complexity of Major Chronic Inflammatory and Degenerative Diseases: A Potential New Systemic Approach to Their Treatment
Current Pharmaceutical Biotechnology Current Acetylcholinesterase-Inhibitors: A Neuroinformatics Perspective
CNS & Neurological Disorders - Drug Targets Designing Multi-Targeted Therapeutics for the Treatment of Alzheimer's Disease
Current Topics in Medicinal Chemistry Molecular Mechanisms of Thiamine Utilization.
Current Molecular Medicine Transdermal Drug Delivery Systems and their Potential in Alzheimer’s Disease Management
CNS & Neurological Disorders - Drug Targets Analysis of Homocysteine in Plasma of Rats Exposed to High-fat Diet and Chronic Unpredictable Mild Stress by LC/ESI-MS/MS
Current Analytical Chemistry BACE1 Deficient Mice: Their Role in Drug Target Validation and Implications for Alzheimers Disease Therapies
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Linking Antimicrobial Potential of Natural Products Derived from Aquatic Organisms and Microbes Involved in Alzheimer’s Disease - A Review
Current Medicinal Chemistry