Abstract
The success of vaccination is directly or indirectly based on the specificity of antigen recognition by T lymphocytes, their efficient activation and expansion, and the generation of vaccine-specific effector and memory cells. These traits are largely dependent on the correct assembly and expression of sufficient number of functional TCR/CD3 complexes in the cell surface. In this review, some of the genetic and epigenetic factors that determine the correct assembly and structure of the TCR/CD3 complex are summarized. Those physiologic or pathologic factors leading to natural variations, or pathologic alterations of the standard that might lead to poor response to vaccination and that could give some possibilities to pharmacological intervention are emphasized.
Keywords: T cell antigen receptor, TCR, CD3, CD247, vaccines
Current Pharmaceutical Design
Title: The TCR/CD3 Complex: Opening the Gate to Successful Vaccination
Volume: 15 Issue: 28
Author(s): Pilar Portoles and Jose M. Rojo
Affiliation:
Keywords: T cell antigen receptor, TCR, CD3, CD247, vaccines
Abstract: The success of vaccination is directly or indirectly based on the specificity of antigen recognition by T lymphocytes, their efficient activation and expansion, and the generation of vaccine-specific effector and memory cells. These traits are largely dependent on the correct assembly and expression of sufficient number of functional TCR/CD3 complexes in the cell surface. In this review, some of the genetic and epigenetic factors that determine the correct assembly and structure of the TCR/CD3 complex are summarized. Those physiologic or pathologic factors leading to natural variations, or pathologic alterations of the standard that might lead to poor response to vaccination and that could give some possibilities to pharmacological intervention are emphasized.
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Cite this article as:
Portoles Pilar and Rojo M. Jose, The TCR/CD3 Complex: Opening the Gate to Successful Vaccination, Current Pharmaceutical Design 2009; 15 (28) . https://dx.doi.org/10.2174/138161209789105199
DOI https://dx.doi.org/10.2174/138161209789105199 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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