Abstract
Disulfide reductases are involved in many functions in the cell, in particular, maintaining the intracellular redox balance. Many classes of these enzymes exist, and their inhibition has served as an effective therapy against different types of human diseases. The involvement of disulfide reductases in various cellular processes is reviewed, and therapeutic strategies against pathogenic bacteria, parasitic infections, and human diseases based on their inhibition are discussed.
Keywords: Disulfide reductase, thioredoxin, glutathione, inhibition, therapeutic target, pathogen, cancer
Current Enzyme Inhibition
Title: Inhibition of Disulfide Reductases as a Therapeutic Strategy
Volume: 5 Issue: 3
Author(s): Nadeem O. Kaakoush and George L. Mendz
Affiliation:
Keywords: Disulfide reductase, thioredoxin, glutathione, inhibition, therapeutic target, pathogen, cancer
Abstract: Disulfide reductases are involved in many functions in the cell, in particular, maintaining the intracellular redox balance. Many classes of these enzymes exist, and their inhibition has served as an effective therapy against different types of human diseases. The involvement of disulfide reductases in various cellular processes is reviewed, and therapeutic strategies against pathogenic bacteria, parasitic infections, and human diseases based on their inhibition are discussed.
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Cite this article as:
Kaakoush O. Nadeem and Mendz L. George, Inhibition of Disulfide Reductases as a Therapeutic Strategy, Current Enzyme Inhibition 2009; 5 (3) . https://dx.doi.org/10.2174/157340809789071164
DOI https://dx.doi.org/10.2174/157340809789071164 |
Print ISSN 1573-4080 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6662 |
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