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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Research Article

Construction of a Subcutaneous Fat Transplantation Model Infected with Mycobacterium

In Press, (this is not the final "Version of Record"). Available online 04 February, 2025
Author(s): Wuliang Diao, Yang Hu, Xiangyu Chen, Weidong Li, Julius K.S.K. Kpegah, Xuan Chen, Mingzhu Wang, Jianda Zhou and Ping Li*
Published on: 04 February, 2025

DOI: 10.2174/0109298673345671250114235930

Abstract

Introduction: Fat grafting procedures for body contouring and cosmetic reconstruction have received widespread attention.

Method: In recent years, there has been an increase in post-fat grafting infections caused by Mycobacterium abscessus (MA), and there is a lack of representative and standardized murine models of infection; therefore, there has been limited research on the treatment of post-fat grafting MA infections. To overcome this challenge, we constructed an MA infection model after fat grafting.

Result: By evaluating skin charge, dermatopathology, and inflammatory markers, we found that the fat graft + 1 × 109 CFU/mL bacterial suspension infection group had significant inflammatory symptoms and elevated inflammatory factors on postoperative day 10.

Conclusion: The model construction process was simple and reproducible, which paves the way for further studies on the impact of MA pathogenesis and the efficacy of new treatments.

Keywords: Fat grafting, mycobacterium abscessus, infection, inflammation, model.


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