Abstract
Introduction: Fat grafting procedures for body contouring and cosmetic reconstruction have received widespread attention.
Method: In recent years, there has been an increase in post-fat grafting infections caused by Mycobacterium abscessus (MA), and there is a lack of representative and standardized murine models of infection; therefore, there has been limited research on the treatment of post-fat grafting MA infections. To overcome this challenge, we constructed an MA infection model after fat grafting.
Result: By evaluating skin charge, dermatopathology, and inflammatory markers, we found that the fat graft + 1 × 109 CFU/mL bacterial suspension infection group had significant inflammatory symptoms and elevated inflammatory factors on postoperative day 10.
Conclusion: The model construction process was simple and reproducible, which paves the way for further studies on the impact of MA pathogenesis and the efficacy of new treatments.
Keywords: Fat grafting, mycobacterium abscessus, infection, inflammation, model.
Current Medicinal Chemistry
Title:Construction of a Subcutaneous Fat Transplantation Model Infected with Mycobacterium
Volume: 32
Author(s): Wuliang Diao, Yang Hu, Xiangyu Chen, Weidong Li, Julius K.S.K. Kpegah, Xuan Chen, Mingzhu Wang, Jianda Zhou and Ping Li*
Affiliation:
- Department of Plastic Surgery of Third Xiangya Hospital, Central South University, Changsha, Hunan, China
Keywords: Fat grafting, mycobacterium abscessus, infection, inflammation, model.
Abstract:
Introduction: Fat grafting procedures for body contouring and cosmetic reconstruction have received widespread attention.
Method: In recent years, there has been an increase in post-fat grafting infections caused by Mycobacterium abscessus (MA), and there is a lack of representative and standardized murine models of infection; therefore, there has been limited research on the treatment of post-fat grafting MA infections. To overcome this challenge, we constructed an MA infection model after fat grafting.
Result: By evaluating skin charge, dermatopathology, and inflammatory markers, we found that the fat graft + 1 × 109 CFU/mL bacterial suspension infection group had significant inflammatory symptoms and elevated inflammatory factors on postoperative day 10.
Conclusion: The model construction process was simple and reproducible, which paves the way for further studies on the impact of MA pathogenesis and the efficacy of new treatments.
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Cite this article as:
Diao Wuliang, Hu Yang, Chen Xiangyu, Li Weidong, Kpegah K.S.K. Julius, Chen Xuan, Wang Mingzhu, Zhou Jianda and Li Ping*, Construction of a Subcutaneous Fat Transplantation Model Infected with Mycobacterium, Current Medicinal Chemistry 2025; 32 () . https://dx.doi.org/10.2174/0109298673345671250114235930
DOI https://dx.doi.org/10.2174/0109298673345671250114235930 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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