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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Mini-Review Article

Smart Applications of Lanthanide Chelates-based Luminescent Probes in Bio-Imaging

In Press, (this is not the final "Version of Record"). Available online 29 January, 2025
Author(s): Maria Chiara Santangelo, Leonardo Lucchesi, Leonardo Papa, Annachiara Rossi, Gaia Egizzo, Giusy Laura Fratello, Lucilla Favero, Mauro Pineschi, Valeria Di Bussolo and Sebastiano Di Pietro*
Published on: 29 January, 2025

DOI: 10.2174/0113895575350677250101060606

Price: $95

Abstract

Luminescent Lanthanide (III) (Ln(III)) bioprobes (LLBs) have been extensively used in the last two decades as intracellular molecular probes in bio-imaging for the efficient revelation of analytes, to signal intracellular events (enzymes/protein activity, antigen-antibody interaction), target specific organelles, and determine parameters of particular biophysical interest, to gain important insights on pathologies or diseases. The choice of using a luminescent Ln(III) coordination compound with respect to a common organic fluorophore is intimately connected to how their photophysical sensitization (antenna effect) can be finely tuned and especially triggered to respond (even quantitatively) to a certain biophysical event, condition or analyte. While there are other reviews focused on how to design chromophoric ligands for an efficient sensitization of Ln(III) ions, both in the visible and NIR region, this review is application-driven: it is a small collection of particularly interesting examples where the LLB’s emissive information is acquired by imaging the emission intensity and/or the fluorescence lifetime (fluorescence lifetime imaging microscopy, FLIM).

Keywords: Lanthanide chelate, molecular probe, bio-imaging, luminescent lanthanide bioprobe, fluorescence lifetime imaging microscopy, Europium, Terbium, Ytterbium.


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