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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Myelination in Bipolar Patients and the Effects of Mood Stabilizers on Brain Anatomy

Author(s): Paolo Brambilla, Marcella Bellani, Ping-Hong Yeh and Jair C. Soares

Volume 15, Issue 22, 2009

Page: [2632 - 2636] Pages: 5

DOI: 10.2174/138161209788957519

Price: $65


In this review, we debate the evidence for abnormal white matter microstructure and myelination in bipolar disorder, as mainly detected by diffusion tensor imaging (DTI) studies. The effects of mood stabilizers on white matter are discussed, based on available findings from human and animal studies. Last, perspectives in this field of research are also drawn.

Keywords: Diffusion imaging, white matter, prefrontal cortex, hippocampus, amygdala, corpus callosum, lithium, valproate

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