In Silico Pharmacogenomic Assessment of Glucagon-like Peptide-1 (GLP1) Agonists and the Genetic Addiction Risk Score (GARS) Related Pathways: Implications for Suicidal Ideation and Substance Use Disorder

Abuse, S.; Administration, M.H.S. Key substance use and mental health indicators in the United States: Results from the 2018 National survey on drug use and health., 2019. Available from: https://www.samhsa.gov/data/sites/default/files/cbhsq-reports/NSDUHNationalFindingsReport2018/NSDUHNationalFindingsReport2018.htm

Organization, W.H. Global status report on road safety 2018; World Health Organization, 2019.

Kohn, R.; Saxena, S.; Levav, I.; Saraceno, B. The treatment gap in mental health care. Bull. World Health Organ., 2004, 82(11), 858-866.
[PMID: 15640922]

Dahlgren, A.; Wargelius, H.L.; Berglund, K.J.; Fahlke, C.; Blennow, K.; Zetterberg, H.; Oreland, L.; Berggren, U.; Balldin, J. Do alcohol-dependent individuals with DRD2 A1 allele have an increased risk of relapse? A pilot study. Alcohol Alcohol., 2011, 46(5), 509-513.
[http://dx.doi.org/10.1093/alcalc/agr045] [PMID: 21613303]

Crime., U.N.O.o.D.a., World Drug Report 2023; United Nations: New York, NY, 2023.

Organization, W.H. WHO global report on trends in prevalence of tobacco use 2000-2030; World Health Organization, 2024.

Dai, X.; Gakidou, E.; Lopez, A.D. Evolution of the global smoking epidemic over the past half century: Strengthening the evidence base for policy action. Tob. Control, 2022, 31(2), 129-137.
[http://dx.doi.org/10.1136/tobaccocontrol-2021-056535] [PMID: 35241576]

WHO Report on GLOBAL TOBACCO Epidemic; 2023; Protect people for tobacco smoke. WHO 2023.

Howes, O.D.; Kapur, S. The dopamine hypothesis of schizophrenia: version III-the final common pathway. Schizophr. Bull., 2009, 35(3), 549-562.
[http://dx.doi.org/10.1093/schbul/sbp006] [PMID: 19325164]

Klausen, M.K.; Thomsen, M.; Wortwein, G.; Fink-Jensen, A. The role of glucagon-like peptide 1 (GLP-1) in addictive disorders. Br. J. Pharmacol., 2022, 179(4), 625-641.
[http://dx.doi.org/10.1111/bph.15677] [PMID: 34532853]

Zhang, X.; Belousoff, M.J.; Zhao, P.; Kooistra, A.J.; Truong, T.T.; Ang, S.Y.; Underwood, C.R.; Egebjerg, T.; Šenel, P.; Stewart, G.D. Differential GLP-1R binding and activation by peptide and non-peptide agonists. Mol. Cell, 2020, 80(3), 485-500.

Volkow, N.D.; Wise, R.A.; Baler, R. The dopamine motive system: Implications for drug and food addiction. Nat. Rev. Neurosci., 2017, 18(12), 741-752.
[http://dx.doi.org/10.1038/nrn.2017.130] [PMID: 29142296]

Blum, K.; Kozlowski, G. Ethanol and neuromodulator interactions: A cascade model of reward. In: Alcohol and Behavior; VSP Press, 1990, pp. 131-149.

Rebosio, C.; Balbi, M.; Passalacqua, M.; Ricciarelli, R.; Fedele, E. Presynaptic GLP-1 receptors enhance the depolarization-evoked release of glutamate and GABA in the mouse cortex and hippocampus. Biofactors, 2018, 44(2), 148-157.
[http://dx.doi.org/10.1002/biof.1406] [PMID: 29265673]

Brodnik, Z.D.; Batra, A.; Oleson, E.B.; España, R.A. Local GABAA receptor-mediated suppression of dopamine release within the nucleus accumbens. ACS Chem. Neurosci., 2019, 10(4), 1978-1985.
[http://dx.doi.org/10.1021/acschemneuro.8b00268] [PMID: 30253088]

Chuong, V.; Farokhnia, M.; Khom, S.; Pince, C.L.; Elvig, S.K.; Vlkolinsky, R.; Marchette, R.C.N.; Koob, G.F.; Roberto, M.; Vendruscolo, L.F.; Leggio, L. The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission. JCI Insight, 2023, 8(12), e170671.
[http://dx.doi.org/10.1172/jci.insight.170671] [PMID: 37192005]

Andreadis, P.; Karagiannis, T.; Malandris, K.; Avgerinos, I.; Liakos, A.; Manolopoulos, A.; Bekiari, E.; Matthews, D.R.; Tsapas, A. Semaglutide for type 2 diabetes mellitus: A systematic review and meta-analysis. Diabetes Obes. Metab., 2018, 20(9), 2255-2263.
[http://dx.doi.org/10.1111/dom.13361] [PMID: 29756388]

Htike, Z.Z.; Zaccardi, F.; Papamargaritis, D.; Webb, D.R.; Khunti, K.; Davies, M.J. Efficacy and safety of glucagon-like peptide-1 receptor agonists in type 2 diabetes: A systematic review and mixed-treatment comparison analysis. Diabetes Obes. Metab., 2017, 19(4), 524-536.
[http://dx.doi.org/10.1111/dom.12849] [PMID: 27981757]

Gerstein, H.C.; Colhoun, H.M.; Dagenais, G.R.; Diaz, R.; Lakshmanan, M.; Pais, P.; Probstfield, J.; Riesmeyer, J.S.; Riddle, M.C.; Rydén, L.; Xavier, D.; Atisso, C.M.; Dyal, L.; Hall, S.; Rao-Melacini, P.; Wong, G.; Avezum, A.; Basile, J.; Chung, N.; Conget, I.; Cushman, W.C.; Franek, E.; Hancu, N.; Hanefeld, M.; Holt, S.; Jansky, P.; Keltai, M.; Lanas, F.; Leiter, L.A.; Lopez-Jaramillo, P.; Cardona Munoz, E.G.; Pirags, V.; Pogosova, N.; Raubenheimer, P.J.; Shaw, J.E.; Sheu, W.H.H.; Temelkova-Kurktschiev, T.; Abella, M.; Alebuena, A.; Almagro, S.; Amoroso, E.; Anadon, P.; Andreu, E.; Aristimuño, G.; Arzadun, M.; Barbieri, M.; Barcudi, R.; Bartolacci, I.; Bolobanich, G.; Bordonava, A.; Bustamante Labarta, M.; Bustos, B.; Caccavo, A.; Camino, A.; Cantero, M.; Carignano, M.; Cartasegna, L.; Cipullo, M.; Commendatore, V.; Conosciuto, V.; Costamagna, O.; Crespo, C.; Cuello, J.; Cuneo, C.; Cusimano, S.; Dean, S.; Dituro, C.; Dominguez, A.; Farah, M.; Fernandez, A.; Fernandez, F.; Ferrari, A.; Flammia, P.; Fuentealba, J.; Gallardo, K.B.; Garcia, C.; Garcia, D.R.; Garrido, M.; Gavicola, R.; Gerbaudo, C.; Gilli, G.; Giotto, A.P.; Godoy Bolzán, P.; Gomez Vilamajo, O.; Guerlloy, F.; Guridi, C.; Gutierrez Garrido, N.; Hasbani, E.; Hermida, S.; Hominal, M.; Hrabar, A.; Ingaramo, A.; Izzicupo, A.; Krynski, M.; Lagrutta, M.; Lanchiotti, P.; Langhe, M.; Leonard, V.; Llanos, J.; Lopez Santi, R.; Lowenstein, J.; Luquez, C.; Mackinnon, I.; Mana, M.; Manzur, S.; Marino, J.; Martella, C.; Martinez, R.; Matias, R.; Matkovich, J.; Meritano, M.; Montaña, O.; Mulazzi, M.; Ochoa, J.; Paterlini, G.; Pelagagge, M.; Peralta Lopez, M.E.; Prado, A.; Pruyas, L.; Racca, M.; Ricotti, C.; Rodriguez, C.; Romero Vidomlansky, M.; Ronderos, R.; Sadowski, A.L.; Sala, J.; Sánchez, A.; Santoro, A.; Schiavi, L.; Sein, M.; Sernia, V.; Serra, L.; Sicer, M.; Smith, T.; Soso, L.; Sposetti, G.; Steinacher, A.; Stival, J.; Tedesco, J.; Tonin, H.; Tortolo, M.; Ulla, M.; Vallejos, J.; Vico, M.; Virgillito, L.; Visco, V.; Vogel, D.; Waisman, F.; Zaidman, C.; Zucchiatti, N.; Badshah, I.; Cohen, N.; Colman, P.; Colquhoun, D.; Davis, T.; Fourlanos, S.; Fulcher, G.; Hamlyn, J.; Haywood, C.; Hocking, S.; Huchinson, M.; Jeffries, W.; Kyl, M.; Lo, C.; Mah, P.M.; Makepeace, A.; Marope, D.; Nanayakkar, N.; Nankervis, A.; Palmer, N.; Palolus, B.; Pillai, S.; Price, S.; Price, S.; Proietto, J.; Reutens, A.; Rodrigo, N.; Sheikh, A.; Smith, G.; So, M.; Soldatos, G.; Stuckey, B.; Sumithran, P.; Teede, H.; Vora, P.; Williams, L.; Abib, E.; Adão Poço, C.; Alves, É.F.; Andreatta Bernardi Barea, J.; Avezum Oliveira, L.; Castro, D.L.C.; Correa da Cruz, I.; Costa, M.; Cruz, I.; Cunha, S.; Da Silva, M.A.V.; de Carvalho Camara Bona, R.; de Paula, B.; Eliaschewitz, F.; Fazolli, G.; Ferreira Filho, C.A.; Fortes, J.; França, C.; Franco, D.R.; Genestreti, P.R.; Giorgeto, F.; Gonçalves, R.M.; Grossman, M.E.; Henrique Marcelino, A.C.; Hernandes, M.; Horta, A.; Jaeger, C.; Kaneblai, M.; Kauffman Rutenberg, C.; Kerr Saraiva, J.F.; Lemos, M.A.; Maia, L.; Manenti, E.R.; Marques, M.; Melissa Valerio, C.; Moreira, R.; Mothé, F.; Mouco, O.M.; Moura, P.; Moura Jorge, J.C.; Nakashima, C.; Nakazone, M.; Napoli, T.; Nunes, C.; Nunes Salles, J.E.; Oliveira, K.; Oliveira, M.; Pantano, G.S.; Petri, F.; Piazza, L.; Pires, A.C.; Pizzato, P.; Prata, S.; Precoma, D.; Rech, R.; Reis, G.; Reis, H.; Resende, E.; Ribas Fortes, J.; Rodovalho, S.; Rossi dos Santos, F.; Salles, J.E.; Sampaio, C.R.; Santos, T.; Santos dos Santos, V.; Silva e Quadros, T.; Silveira, D.; Siqueira, K.N.; Teireira, M.; Uehara, M.; Valerio, C.; Vianna, H.; Vidotti, M.H.; Visconti, G.L.; Zanella, M.T.; Andreeva, V.; Borisov, R.; Botushanov, N.; Dimitrov, G.; Dimova, K.; Dragoychev, T.; Grigorova, V.; Gushterova, V.; Ivanov, I.; Kocelova, T.; Kurktschiev, D.; Miletieva, M.; Nenkova-Gugusheva, N.; Pancheva, R.; Pavlova, M.; Raev, D.; Spasova, V.; Stoikov, A.; Troev, D.; Yanev, T.; Yoncheva-Mihaylova, M.; Abitbol, A.; Ajala, B.; Alguwaihes, A.; Ardilouze, J-L.; Aris-Jilwan, N.; Arnaout, A.; Aronson, R.; Aslam, N.; Babin, S.; Bailargeon, J-P.; Bailey, A.; Bajaj, H.; Beauchesne, C.; Beca, S.; Belanger, A.; Bell, A.; Bellabarba, D.; Berard, L.; Berenbaum, B.; Bergeron, V.; Berlingieri, J.; Bernier, F.; Bishara, P.; Blank, D.; Blumer, I.; Brault, S.; Breton, D.; Carpentier, A.; Cha, J.; Chandra, P.; Chiasson, J-L.; Conway, J.R.; Couture, G.; Couture, N.; Dagenais, G.; Datta, D.; D’Ignazio, G.; Dumas, R.; Fay, D.; Frechette, A.; Frenette, L.; Fung, D.; Gagnon, N.; Galter, M.; Garon, J.; Gauthier, J.S.; Geadah, C.; Gilbert, J.; Girard, R.; Goldenberg, R.; Grossman, L.D.; Gupta, N.; Halle, J-P.; Hivert, M-F.; Houde, G.; Houlden, R.; Hramiak, I.; Jablonski, T.; Jain, A.J.; Khandwala, H.; Khosla, M.; Lachance, C.; Laflamme, E.; Langlois, M-F.; Larivee, L.; Liutkus, J.; Lochnan, H.; Malik, S.; McDonald, C.; Mehta, P.; Mihailidis, J.; Milot, A.; Narula, P.; Nault, P.; Nayar, A.; Nisker, W.; Ouellet, G.; Palardy, J.; Patel, M.; Paul, T.; Pedersen, S.; Perron, P.; Pesant, M-H.; Poirier, P.; Poulin, M-C.; Punthakee, Z.; Rehman, W.; Ross, S.; Sagar, P.; Saliba, N.; Sandler, S.; Schiffrin, A.; Schlosser, R.; Seth-Sharma, A.; Sherman, M.; Sionit, D.; Sivakumar, T.; Soto, J.; St-Amour, E.; Steen, O.; Sussman, J.; Telner, A.; Tobe, S.; Twum-Barima, D-Y.; Van Zanten, A.; VanRossum, N.; Vecchiarelli, J.; Ward, R.; Wessengel, J.; Weisnagel, S.; Wilderman, I.; Woo, V.; Yakubovich, N.; Yale, J-F.; Yared, Z.; Acevedo, M.; Aguirre, M.L.; Aizman, A.; Barroso, M.S.; Cobos, L.; Danin Vargas, A.; Descalzi, B.; Godoy, G.; Grumberg, E.; Lahsen, R.; Larenas, G.; Ortiz, E.; Paredes, J.; Potthoff, S.; Retamal, E.; Rojas, L.; Salgado, M.; Santibanez, C.; Solis, C.; Stokins, B.; Accini, J.; Acebedo, J.; Agudelo Baena, L.M.; Alarcon, S.; Angel, J.; Arcos, E.; Aroca Martinez, M.; Atuesta, L.; Balaguera, J.; Ballestas, D.; Barrera, S.I.; Barrios Reyes, R.; Bayona, A.; Bermudez, A.; Bernal, D.Z.; Blanquicett, M.; Bravo, V.; Bueno, W.; Burbano Delgado, A.; Cadena, A.; Cadena, A.; Caicedo, S.; Celemin, C.; Consuegra, R.; Contreras Pimienta, C.; Corredor, K.J.; Cure, C.; De La Hoz Rueda, L.D.; Delgado, E.; Diaz, S.; Diego, M.; Donado, A.; Encinales Sanabria, W.; Escobar, J.; Escorcia, G.; Forero, L.; Fuentes, L.; Garcia, M.; Garcia Lozada, H.; Garcia Ortiz, L.; Giraldo, A.; Gomez Gonzalez, L.; Granada, J.; Gutierrez, C.; Henao, N.; Hernandez, E.; Herrera Uejbe, O.M.; Higuera Cobos, J.D.; Ibarra Gómez, J.; Jaimes, E.H.; Jaramillo, M.; Jaramillo, N.; Jaramillo Gomez, C.; Jaramillo Sanchez, M.; Jarava Durán, I.; Lopez Ceballos, C.; Madrid, C.; María Amastha, E.; Mercado, J.; Molina, D.I.; Molina Soto, J.; Montoya, C.; Morales, A.; Muñoz, C.; Orozco, L.A.; Osorio, O.; Palmera Sanchez, J.M.; Peña, A.; Perez, J.; Perez Agudelo, J.; Pérez Amador, G.; Pertuz, C.; Posada, I.; Puerta, C.; Quintero, A.; Quiroz, D.; Rendon, C.; Reyes, A.; Reyes, A.; Ripoll, D.; Rivera, C.; Rocha, M.; Rodriguez, J.F.; Rodriguez Villanueva, K.A.; Rodriguez Zabala, J.E.; Rojas, S.; Romero, M.; Rosero, R.; Rosillo Cardenas, A.R.; Rueda, L.; Sanchez, G.; Sanchez, T.; Sotomayor Herazo, A.; Suarez, M.; Torres, M.; Trujillo, F.; Urina, M.; Van Strahlen, L.; Velandia, C.; Velasquez Guzman, C.; Velazquez, E.; Vidal Prada, T.; Yepez Alvaran, J.P.; Zarate, D.; Andelova, J.; Benesova, R.; Buzova, B.; Cech, V.; Chodova, I.; Choura, M.; Dufka, A.; Gamova, A.; Gorgol, J.; Hala, T.; Havlova, H.; Hlavkova, D.; Horanska, P.; Ilcisin-Valova, J.; Jenickova, P.; Jerabek, O.; Kantorova, I.; Kolomaznikova, K.; Kopeckova, I.; Kopeckova, M.; Linhart, K.; Linhart, T.; Malecha, J.; Malicherova, E.; Neubauerova, D.; Oznerova, M.; Partys, R.; Pederzoliova, E.; Petrusova, M.; Prymkova, V.; Racicka, E.; Reissova, I.; Roderova, E.; Stanek, L.; Striova, A.; Svarcova, D.; Svoboda, P.; Szeghy Malicharova, E.; Urge, J.; Vesely, L.; Wasserburger, B.; Wasserburgerova, H.; Zahumensky, E.; Zamrazil, V.; Alawi, H.; Anastasiadis, E.; Axthelm, E.; Bieler, T.; Buhrig, C.; Degtyareva, E.; Dellanna, F.; Derwahl, K-M.; Diessel, S.; Dogiami, B.; Dorn-Weitzel, K.; Ernst, M.; Faulmann, G.; Fetscher, B.; Forst, T.; Freyer-Lahres, G.; Funke, K.; Ganz, X.; Gleixner, C.; Hanefeld, C.; Heinrichs, S.; Helleberg, S.; Henkel, E.; Hetzel, G.R.; Hoffmann, C.; Jacob, F.; Jacob, S.; John, F.; Jonczyk, A.; Kamke, W.; Klein, C.; Kleinhardt, M.; Kleophas, W.; Kosch, C.; Kreutzmann, K.; Kühn, A.; Lee-Barkey, Y.H.; Lier, A.; Maatouk, S.; Minnich, J.; Mitry, M.; Muessig, I.; Nicula, D.; Niemann, M.; Nothroff, J.; Ott, P.; Pfuetzner, A.; Pfützner, A.; Pistrosch, F.; Pohl, W.; Prochazkova, Z.; Retkowska, M.; Rosin, H.; Sachsenheimer, D.; Samer, H.; Sanuri, M.; Schaefer, A.; Schaper, F.; Schulze, E-D.; Schulze, M.; Schumann, M.; Segiet, T.; Sowa, V.; Stahl, H-D.; Steinfeldt, F.; Teige, M.; Trieb, B.; Tschoepe, D.; Uebel, P.; Warken, B.; Weigmann, I.; Weyland, K.; Wilhelm, K.; Balo, T.; Balsay, M.; Bende, I.; Bezzegh, K.; Birkus, Z.; Buday, B.; Csomai, M.; Deak, L.; Dezso, E.; Faludi, P.; Faluvegi, M.; Fazekas, I.; Feher, A.; Fejer, C.; Finta, E.; Fulcz, A.; Gaal, Z.; Gurzo, M.; Hati, K.; Herczeg, G.; Jozsef, I.; Juhasz, M.; Keltai, K.; Koranyi, L.; Kulcsar, E.; Kun, K.; Laczko, A.; Literáti-Nagy, B.; Mezo, I.; Mileder, M.; Moricz, I.; Nagy, K.; Nagybaczoni, B.; Nemeth, C.; Oze, A.; Pauer, J.; Peterfai, E.; Polocsanyi, B.; Poor, F.; Reiber, I.; Salamon, C.; Sebestyen, J.; Torok, I.; Tuu, M.; Varga, A.; Vass, V.; Ahn, C.M.; Ahn, C. ByungWon, P.; Chang, H-J.; Chang, K.; Choi, E-Y.; Choi, H.S.; Chung, J-W.; Hong, B-K.; Hong, Y.J.; Hyon, M.S.; Jeong, M.H.; Kang, S.; Kim, B-K.; Kim, J-H.; Kim, J.H.; Kim, K-S.; Kim, K-S.; Kim, M.H.; Kim, P-J.; Kim, S-K.; Kim, Y-S.; Kim, Y.K.; Koh, Y.S.; Kwon, H.M.; Lee, B.K.; Lee, B-W.; Lee, J.B.; Lee, M-M.; Lim, Y-M.; Min, P.K.; Park, J.S.; Park, J.; Park, K.H.; Park, S.; Pyun, W.B.; Rim, S.J.; Ryu, D-R.; Seo, H-S.; Seung, K.B.; Shin, D-H.; Sim, D.S.; Yoon, Y.W.; Andersone, I.; Babicka, K.; Balcere, I.; Barons, R.; Capkovska, I.; Geldnere, K.; Grigane, I.; Jegere, B.; Lagzdina, I.; Mora, L.; Pastare, S.; Ritenberga, R.; Romanova, J.; Saknite, I.; Sidlovska, N.; Sokolova, J.; Steina, S.; Strizko, I.; Teterovska, D.; Vizina, B.; Barsiene, L.; Belozariene, G.; Daugintyte-Petrusiene, L.; Drungiliene, N.; Garsviene, N.; Grigiene, A.; Grizas, V.; Jociene, V.; Kalvaitiene, D.; Kaupiene, J.; Kavaliauskiene, J.; Kozloviene, D.; Lapteva, I.; Maneikiene, B.; Marcinkeviciene, J.; Markauskiene, V.; Meiluniene, S.; Norkus, A.; Norviliene, R.; Petrenko, V.; Radzeviciene, R.; Sakalyte, G.; Urbonas, G.; Urbutiene, S.; Vasiliauskas, D.; Velickiene, D.; Aguilar, C.; Alcocer, M.; Avalos-Ramirez, J.A.; Banda-Elizondo, R.; Bricio-Ramirez, R.; Cardenas, M.K.; Cavazos, F.; Chapa, J.; Cienfuegos, E.; De la Peña, A.; de la Peña Topete, G.; De los Rios Ibarra, M.O.; Elias, D.; Flores-Moreno, C.; Garcia, H.P.; Gonzalez, L.G.; Guerra Moya, R.L.; Guerra-Lopez, A.; Hernandez, B.R.; Herrera, C.C.; Herrera-Marmolejo, M.; Islas-Palacios, N.; Lopez, E.; Lopez, F.; Lopez, A.A.; Luna, C.R.I.; Morales, V.E.; Moreno-Virgen, G.; Parra Perez, R.L.; Pascoe, G.S.; Peralta-Cantu, I.; Previn, R.; Ramirez, R.; Ramirez, R.; Ramos, Z.M.G.; Rodriguez, M.; Salgado-Sedano, R.; Sanchez-Aguilar, A.C.; Santa Rosa Franco, E.; Sauque-Reyna, L.; Suarez Otero, R.; Torres, I.; Velarde-Harnandez, E.; Villagordoa, J.; Villeda-Espinoza, E.; Vital-Lopez, J.; Zavala- Bello, C.J.; Baker, J.; Barrington-Ward, E.; Brownless, T.; Carroll, R.; Carson, S.; Choe, M.; Corin, A.; Corley, B.; Cutfield, R.; Dalaman, N.; Dixon, P.; Drury, P.; Dyson, K.; Florkowski, C.; Ford, M.; Frengley, W.; Helm, C.; Katzen, C.; Kerr, J.; Khanolkar, M.; Kim, D.; Koops, R.; Krebs, J.; Leikis, R.; Low, K.; Luckey, A.; Luke, R.; Macaulay, S.; Marks, R.; McNamara, C.; Millar-Coote, D.; Miller, S.; Mottershead, N.; Reid, J.; Robertson, N.; Rosen, I.; Rowe, D.; Schmiedel, O.; Scott, R.; Sebastian, J.; Sheahan, D.; Stiebel, V.; Ternouth, I.; Tofield, C.; Venter, D.; Williams, M.; Williams, M.; Wu, F.; Young, S.; Arciszewska, M.; Bochenek, A.; Borkowski, P.; Borowy, P.; Chrzanowski, T.; Czerwinski, E.; Dwojak, M.; Grodzicka, A.; Janiec, I.; Jaruga, J.; Jazwinska-Tarnawska, E.K.; Jedynasty, K.; Juzwiak-Czapiewska, D.; Karczewicz-Janowska, J.; Konieczny, J.; Konieczny, M.; Korol, M.; Kozina, M.; Krzyzagorska, E.; Kucharczyk-Petryka, E.; Laz, R.; Majchrzak, A.; Mrozowska, Z.; Mularczyk, M.; Nowacka, E.; Peczynska, J.; Petryka, R.; Pietrzak, R.; Pisarczyk-Wiza, D.; Rozanska, A.; Ruzga, Z.; Rzeszotarska, E.; Sacha, M.; Sekulska, M.; Sidorowicz-Bialynicka, A.; Stasinska, T.; Strzelecka-Sosik, A.; Swierszcz, T.; Szymkowiak, K.M.; Turowska, O.; Wisniewska, K.; Wiza, M.; Wozniak, I.; Zelazowska, K.; Ziolkowska-Gawron, B.; Zytkiewicz-Jaruga, D.; Albota, A.; Alexandru, C.; Avram, R.; Bala, C.; Barbonta, D.; Barbu, R.; Braicu, D.; Calutiu, N.; Catrinoiu, D.; Cerghizan, A.; Ciorba, A.; Craciun, A.; Doros, R.; Duma, L.; Dumitrache, A.; Ferariu, I.; Ferician Moza, A.; Ghergan, A.; Ghise, G.; Graur, M.; Gribovschi, M.; Mihai, B.; Mihalache, L.; Mihalcea, M.; Mindrescu, N.; Morosanu, M.; Morosoanu, A.; Mota, M.; Moza, A.; Nafornita, V.; Natea, N.; Nicodim, S.; Nita, C.; Onaca, A.; Onaca, M.; Pop, C.; Pop, L.; Popa, A.; Popescu, A.; Pruna, L.; Roman, G.; Rosu, M.; Sima, A.; Sipciu, D.; Sitterli-Natea, C.N.; Szilagyi, I.; Tapurica, M.; Tase, A.; Tutescu, A-C.; Vanghelie, L.; Verde, I.; Vlad, A.; Zarnescu, M.; Akhmetov, R.; Allenova, I.; Avdeeva, I.; Baturina, O.; Biserova, I.; Bokovin, N.; Bondar, I.; Burova, N.; Chufeneva, G.; Chumachek, E.; Demidova, M.; Demin, A.; Drobysheva, V.; Egorova, I.; Esenyan, L.; Gelig, E.; Gilyarevsky, S.; Golshmid, M.; Goncharov, A.; Gorbunova, A.; Gordeev, I.; Gorelysheva, V.; Goryunova, T.; Grebenshchikova, I.; Ilchenko, R.; Ivannikova, M.; Karabalieva, S.; Karpeeva, J.; Khaykina, E.; Kobalava, Z.; Kononenko, I.; Korolik, O.; Korshunova, A.; Kostenko, V.; Krasnopevtseva, I.; Krylova, L.; Kulkova, P.; Kuzmina, I.; Ledyaeva, A.; Levashov, S.; Lokhovinina, N.; Lvov, V.; Martirosyan, N.; Nedogoda, S.; Nilk, R.; Osmolovskaya, Y.; Panov, A.; Paramonova, O.; Pavlova, E.; Pekareva, E.; Petunina, N.; Ponamareva, S.; Reshedko, G.; Salasyuk, A.; Sepkhanyan, M.; Serebrov, A.; Shabelnikova, O.; Skvortsov, A.; Smirnova, O.; Spiridonova, O.; Strogova, S.; Taratukhin, E.; Tereschenko, S.; Trukhina, L.; Tsarkova, O.; Tsoma, V.; Tumarov, F.; Tyan, N.; Tyurina, T.; Villevalde, S.; Yankovaya, E.; Zarutskaya, L.; Zenkova, E.; Badat, A.; Bester, F.; Blignaut, S.; Blom, D.; Booysen, S.; Boyd, W.; Brice, B.; Brown, S.; Burgess, L.; Cawood, R.; Coetzee, K.; Conradie, H.; Cronje, T.; de Jong, D.; Ellis, G.; Emanuel, S.; Engelbrecht, I.; Foulkes, S.; Fourie, D.; Gibson, G.; Govender, T.; Hansa, S.; Hemus, A.C.; Hendricks, F.; Heradien, M.; Holmgren, C.; Hoosain, Z.; Horak, E.; Howard, J.; Immink, I.; Janari, E.; Jivan, D.; Klusmann, K.; Labuschagne, W.; Lai, Y.; Latiff, G.; Lombaard, J.; Lottering, H.; Meeding, R.; Middlemost, S.; Mitha, H.; Mitha, I.; Mkhwanazi, S.; Moodley, R.; Murray, A.; Musungaie, D.; Osman, Y.; Peacey, K.; Pillay-Ramaya, L.; Pretorius, C.; Prozesky, H.; Sarvan, M.; Scholtz, E.; Sebesteny, A.; Skinner, B.; Skriker, M.; Smit, M.; Stapelberg, A-M.; Swanepoel, N.; Urbach, D.; van Aswegen, D.; van Zyl, F.; Van Zyl, L.; Venter, E.; Wadvalla, S.; Wing, J.; Wolmarans, K.; Abreu, C.; Aguilà, P.; Aguilera, E.; Alonso, N.; Alvarez, C.; Cajas, P.; Castro, J.C.; Codinachs, R.; Contreras, J.; Coves, M.J.; Fajardo, C.; Ferrer, J.C.; Font, N.; Garcia, M.; Gil, M.A.; Gomez, F.; Gomez, L.A.; Gonzalbez, J.; Griera, J.L.; Masmiquel, L.; Mauricio, D.; Narejos Perez, S.; Nicolau, J.A.; Noheda Contreras, O.; Olivan, J.; Olivares, J.; Ortega, E.; Pellitero, S.; Pertusa, S.; Rius, F.; Rodriguez, I.; Sánchez-Juan, C.; Santos, D.; Soldevila, B.; Subias, D.; Terns, M.; Trescoli, C.; Vilaplana, J.; Villanueva, A.; Albo, J.; Antus, K.; Axelsson, M.; Bergström, L.; Binsell-Gerdin, E.; Boman, K.; Botond, F.; Dotevall, A.; Graipe, A.; Jarnet, C.; Kaminska, J.; Kempe, A.; Korhonen, M.; Linderfalk, C.; Liu, B.; Ljungstroem, K.; Ljungström, K.; Malmqvist, L.; Mellbin, L.; Mooe, T.; Nicol, P.; Norrby, A.; Ohlsson, A.; Rosengren, A.; Saaf, J.; Salmonsson, S.; Strandberg, O.; Svensson, K-A.; Tengmark, B-O.; Tsatsaris, G.; Ulvenstam, A.; Vasko, P.; Chang, C-T.; Chang, H-M.; Chen, J-F.; Chen, T-P.; Chung, M-M.; Fu, C-P.; Hsia, T-L.; Hua, S-C.; Kuo, M-C.; Lee, C.; Lee, I-T.; Liang, K-W.; Lin, S.Y.; Lu, C-H.; Ma, W-Y.; Pei, D.; Shen, F-C.; Su, C-C.; Su, S-W.; Tai, T-S.; Tsai, W-N.; Tsai, Y-T.; Tung, S-C.; Wang, J-S.; Yu, H-I.; Al-Qaissi, A.; Arutchelvam, V.; Atkin, S.; Au, S.; Aye, M.M.; Bain, S.; Bejnariu, C.; Bell, P.; Bhatnagar, D.; Bilous, R.; Black, N.; Brennan, U.; Brett, B.; Bujanova, J.; Chow, E.; Collier, A.; Combe, A.; Courtney, C.; Courtney, H.; Crothers, J.; Eavis, P.; Elliott, J.; Febbraro, S.; Finlayson, J.; Gandhi, R.; Gillings, S.; Hamling, J.; Harper, R.; Harris, T.; Hassan, K.; Heller, S.; Jane, A.; Javed, Z.; Johnson, T.; Jones, S.; Kennedy, A.; Kerr, D.; Kilgallon, B.; Konya, J.; Lindsay, J.; Lomova-Williams, L.; Looker, H.; MacFarlane, D.; Macrury, S.; Malik, I.; McCrimmon, R.; McKeith, D.; McKnight, J.; Mishra, B.; Mukhtar, R.; Mulligan, C.; O’Kane, M.; Olateju, T.; Orpen, I.; Richardson, T.; Rooney, D.; Ross, S.B.; Sathyapalan, T.; Siddaramaiah, N.; Sit, L.E.; Stephens, J.; Turtle, F.; Wakil, A.; Walkinshaw, E.; Ali, A.; Anderson, R.; Arakaki, R.; Aref, O.; Ariani, M.K.; Arkin, D.; Banarer, S.; Barchini, G.; Bhan, A.; Branch, K.; Brautigam, D.; Brietzke, S.; Brinas, M.; Brito, Y.; Carter, C.; Casagni, K.; Casula, S.; Chakko, S.; Charatz, S.; Childress, D.; Chow, L.; Chustecka, M.; Clarke, S.; Cohen, L.; Collins, B.; Colon Vega, G.; Comulada-Rivera, A.; Cortes-Maisonet, G.; Davis, M.; de Souza, J.; Desouza, C.; Dinnan, M.; Duffy-Hidalgo, B.; Dunn, B.; Dunn, J.; Elman, M.; Felicetta, J.; Finkelstein, S.; Fitz-Patrick, D.; Florez, H.; Forker, A.; Fowler, W.; Fredrickson, S.; Freedman, Z.; Gainey Narron, B.; Gainey-Ferree, K.; Gardner, M.; Gastelum, C.; Giddings, S.; Gillespie, E.; Gimness, M.P.; Goldstein, G.; Gomes, M.; Gomez, N.; Gorman, T.; Goswami, K.; Graves, A.; Hacking, S.; Hall, C.; Hanson, L.; Harman, S.; Heber, D.; Henry, R.; Hiner, J.; Hirsch, I.; Hollander, P.; Hooker, T.; Horowitz, B.; Hoste, L.; Huang, L.; Huynh, M.; Hyman, D.; Idriss, S.; Iranmanesh, A.; Karounos, D.; Kashyap, M.; Katz, L.; Kaye, W.; Khaiton, Y.; Khardori, R.; Kitchen, T.; Klein, A.; Knffem, W.; Kosiborod, M.; Kreglinger, N.; Kruger, D.; Kumar, A.; Laboy, I.; Larrabee, P.; Larrick, L.; Lawson, D.; Ledet, M.; Lenhard, J.; Levy, J.; Li, G.; Li, Z.; Lieb, D.; Limcolioc, A.; Lions-Patterson, J.; Lorber, D.; Lorch, D.; Lorrello, M.; Lu, P.; Lucas, K.J.; Ma, S-L.; MacAdams, M.; Magee, M.; Magno, A.; Mahakala, A.R.; Marks, J.; McCall, A.; McClanahan, W., Jr; McClary, C.; Melendez, L.; Melish, J.; Michaud, D.; Miller, C.; Miller, N.; Mora, P.; Moten, M.; Mudaliar, S.; Myrick, G.; Narayan, P.; Nassif, M.; Neri, K.; Newton, T.; Niblack, P.; Nicol, P.; Nyenwe, E.; Odugbesan, A.O.; Okorocha, Y.; Ortiz, C.R.; Osei, K.; Palermo, C.; Patel, H.; Patel, K.; Pau, C.; Perley, M.; Plevin, S.; Plummer, E.; Powell, R.; Qintar, M.; Rawls, R.; Reyes-Castano, J.; Reynolds, L.; Richards, R.; Rosenstock, J.; Rowe, C.; Saleh, J.; Sam, S.; Sanchez, A.; Sander, D.; Sanderson, B.; Savin, V.; Seaquist, E.; Shah, J.; Shi, S.; Shivaswamy, V.; Shlotzhauer, T.; Shore, D.; Skukowski, B.; Soe, K.; Solheim, V.; Soufer, J.; Steinberg, H.; Steinsapir, J.; Tarkington, P.; Thayer, D.; Thomson, S.; Thrasher, J.; Tibaldi, J.; Tjaden, J.; Tores, O.; Trence, D.; Trikudanathan, S.; Ullal, J.; Uwaifo, G.; Vo, A.; Vu, K.; Walia, D.; Weiland, K.; Whitehouse, F.; Wiegmann, T.; Wyne, K.; Wynne, A.; Yuen, K.; Zaretzky, J.; Zebrack, J.; Zieve, F.; Zigrang, W. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): A double-blind, randomised placebo-controlled trial. Lancet, 2019, 394(10193), 121-130.
[http://dx.doi.org/10.1016/S0140-6736(19)31149-3] [PMID: 31189511]

Marso, S.P.; Bain, S.C.; Consoli, A.; Eliaschewitz, F.G.; Jódar, E.; Leiter, L.A.; Lingvay, I.; Rosenstock, J.; Seufert, J.; Warren, M.L.; Woo, V.; Hansen, O.; Holst, A.G.; Pettersson, J.; Vilsbøll, T. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N. Engl. J. Med., 2016, 375(19), 1834-1844.
[http://dx.doi.org/10.1056/NEJMoa1607141] [PMID: 27633186]

Marso, S.P.; Daniels, G.H.; Brown-Frandsen, K.; Kristensen, P.; Mann, J.F.E.; Nauck, M.A.; Nissen, S.E.; Pocock, S.; Poulter, N.R.; Ravn, L.S.; Steinberg, W.M.; Stockner, M.; Zinman, B.; Bergenstal, R.M.; Buse, J.B. Liraglutide and cardiovascular outcomes in type 2 diabetes. N. Engl. J. Med., 2016, 375(4), 311-322.
[http://dx.doi.org/10.1056/NEJMoa1603827] [PMID: 27295427]

Takaoka, Y.; Mizuno, A.; Kanie, T.; Yoneoka, D.; Suzuki, T.; Nishikawa, Y.; Tam, W.W.S.; Morze, J.; Rynkiewicz, A.; Xin, Y.; Wu, O. Dipeptidyl peptidase-4 inhibitors, glucagon-like peptide 1 receptor agonists and sodium-glucose co-transporter-2 inhibitors for people with cardiovascular disease: A network meta-analysis. Cochrane Database Syst. Rev., 2021, 10(10), CD013650.
[http://dx.doi.org/10.1002/14651858]

Raad, M.; López, W.O.C.; Sharafshah, A.; Assefi, M.; Lewandrowski, K.U. Personalized medicine in cancer pain management. J. Pers. Med., 2023, 13(8), 1201.
[http://dx.doi.org/10.3390/jpm13081201] [PMID: 37623452]

Suchankova, P.; Yan, J.; Schwandt, M.L.; Stangl, B.L.; Caparelli, E.C.; Momenan, R.; Jerlhag, E.; Engel, J.A.; Hodgkinson, C.A.; Egli, M.; Lopez, M.F.; Becker, H.C.; Goldman, D.; Heilig, M.; Ramchandani, V.A.; Leggio, L. The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: Evidence from human genetic association studies and a mouse model of alcohol dependence. Transl. Psychiatry, 2015, 5(6), e583-e583.
[http://dx.doi.org/10.1038/tp.2015.68] [PMID: 26080318]

Sabaie, H.; Khorami Rouz, S.; Kouchakali, G.; Heydarzadeh, S.; Asadi, M.R.; Sharifi-Bonab, M.; Hussen, B.M.; Taheri, M.; Ayatollahi, S.A.; Rezazadeh, M. Identification of potential regulatory long non-coding RNA-associated competing endogenous RNA axes in periplaque regions in multiple sclerosis. Front. Genet., 2022, 13, 1011350.
[http://dx.doi.org/10.3389/fgene.2022.1011350] [PMID: 36324503]

Hernandez, N.S.; Weir, V.R.; Ragnini, K.; Merkel, R.; Zhang, Y.; Mace, K.; Rich, M.T.; Christopher, P.R.; Schmidt, H.D. GLP-1 receptor signaling in the laterodorsal tegmental nucleus attenuates cocaine seeking by activating GABAergic circuits that project to the VTA. Mol. Psychiatry, 2021, 26(8), 4394-4408.
[http://dx.doi.org/10.1038/s41380-020-00957-3] [PMID: 33257815]

Liu, Z.P.; Wu, C.; Miao, H.; Wu, H. RegNetwork: An integrated database of transcriptional and post-transcriptional regulatory networks in human and mouse. Database (Oxford), 2015, 2015, bav095.
[http://dx.doi.org/10.1093/database/bav095] [PMID: 26424082]

Qiao, L.; Lu, C.; Zang, T.; Dzyuba, B.; Shao, J. Maternal GLP-1 receptor activation inhibits fetal growth. Am. J. Physiol. Endocrinol. Metab., 2024, 326(3), ajpendo.00361.2023.
[http://dx.doi.org/10.1152/ajpendo.00361.2023] [PMID: 38197791]

Marballi, K.K.; Alganem, K.; Brunwasser, S.J.; Barkatullah, A.; Meyers, K.T.; Campbell, J.M.; Ozols, A.B.; Mccullumsmith, R.E.; Gallitano, A.L. Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia. Transl. Psychiatry, 2022, 12(1), 320.
[http://dx.doi.org/10.1038/s41398-022-02069-8] [PMID: 35941129]

Aranäs, C.; Edvardsson, C.E.; Shevchouk, O.T.; Zhang, Q.; Witley, S.; Blid, S.S.; Zentveld, L.; Vallöf, D.; Tufvesson-Alm, M.; Jerlhag, E. Semaglutide reduces alcohol intake and relapse-like drinking in male and female rats. EBioMedicine, 2023, 93, 104642.
[http://dx.doi.org/10.1016/j.ebiom.2023.104642] [PMID: 37295046]

Fan, X.; Chen, H.; Jiang, F.; Xu, C.; Wang, Y.; Wang, H.; Li, M.; Wei, W.; Song, J.; Zhong, D.; Li, G. Comprehensive analysis of cuproptosis-related genes in immune infiltration in ischemic stroke. Front. Neurol., 2023, 13, 1077178.
[http://dx.doi.org/10.3389/fneur.2022.1077178] [PMID: 36818726]

Jerlhag, E. The therapeutic potential of glucagon-like peptide-1 for persons with addictions based on findings from preclinical and clinical studies. Front. Pharmacol., 2023, 14, 1063033.
[http://dx.doi.org/10.3389/fphar.2023.1063033] [PMID: 37063267]

Tavares, G.; Rosendo-Silva, D.; Simões, F.; Eickhoff, H.; Marques, D.; Sacramento, J.F.; Capucho, A.M.; Seiça, R.; Conde, S.V.; Matafome, P. Circulating dopamine is regulated by dietary glucose and controls glucagon-like 1 peptide action in white adipose tissue. Int. J. Mol. Sci., 2023, 24(3), 2464.
[http://dx.doi.org/10.3390/ijms24032464] [PMID: 36768789]

Zhang, L.; Li, C.; Zhang, Z.; Zhang, Z.; Jin, Q.Q.; Li, L.; Hölscher, C. DA5-CH and semaglutide protect against neurodegeneration and reduce α-Synuclein levels in the 6-OHDA parkinson’s disease rat model. Parkinsons Dis., 2022, 2022(1), 1-11.
[http://dx.doi.org/10.1155/2022/1428817] [PMID: 36419409]

Zhu, C.; Li, H.; Kong, X.; Wang, Y.; Sun, T.; Wang, F. Possible mechanisms underlying the effects of glucagon-like peptide-1 receptor agonist on cocaine use disorder. Front. Pharmacol., 2022, 13, 819470.
[http://dx.doi.org/10.3389/fphar.2022.819470] [PMID: 35300299]

Konanur, V.R.; Hsu, T.M.; Kanoski, S.E.; Hayes, M.R.; Roitman, M.F. Phasic dopamine responses to a food-predictive cue are suppressed by the glucagon-like peptide-1 receptor agonist Exendin-4. Physiol. Behav., 2020, 215, 112771.
[http://dx.doi.org/10.1016/j.physbeh.2019.112771] [PMID: 31821815]

Liu, C.; Liu, W.H.; Yang, W.; Chen, L.; Xue, Y.; Chen, X.Y. GLP-1 modulated the firing activity of nigral dopaminergic neurons in both normal and parkinsonian mice. Neuropharmacology, 2024, 252, 109946.
[http://dx.doi.org/10.1016/j.neuropharm.2024.109946] [PMID: 38599494]

Merkel, R.; Hernandez, N.; Weir, V.; Zhang, Y.; Rich, M.T.; Crist, R.C.; Reiner, B.C.; Schmidt, H.D. An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking. bioRxiv, 2024, 2024.06.
[http://dx.doi.org/10.1101/2024.06.20.599574]

Fortin, S.M.; Roitman, M.F. Central GLP-1 receptor activation modulates cocaine-evoked phasic dopamine signaling in the nucleus accumbens core. Physiol. Behav., 2017, 176, 17-25.
[http://dx.doi.org/10.1016/j.physbeh.2017.03.019] [PMID: 28315693]

Reddy, I.A.; Pino, J.A.; Weikop, P.; Osses, N.; Sørensen, G.; Bering, T.; Valle, C.; Bluett, R.J.; Erreger, K.; Wortwein, G.; Reyes, J.G.; Graham, D.; Stanwood, G.D.; Hackett, T.A.; Patel, S.; Fink-Jensen, A.; Torres, G.E.; Galli, A. Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels. Transl. Psychiatry, 2016, 6(5), e809-e809.
[http://dx.doi.org/10.1038/tp.2016.86] [PMID: 27187231]

Elasbali, A.M.; Al-Soud, W.A.; Mousa Elayyan, A.E.; Al-Oanzi, Z.H.; Alhassan, H.H.; Mohamed, B.M.; Alanazi, H.H.; Ashraf, M.S.; Moiz, S.; Patel, M.; Patel, M.; Adnan, M. Integrating network pharmacology approaches for the investigation of multi-target pharmacological mechanism of 6-shogaol against cervical cancer. J. Biomol. Struct. Dyn., 2023, 41(23), 14135-14151.
[http://dx.doi.org/10.1080/07391102.2023.2191719] [PMID: 36943780]

Falk, S.; Petersen, J.; Svendsen, C.; Romero-Leguizamón, C.R.; Jørgensen, S.H.; Krauth, N.; Ludwig, M.Q.; Lundø, K.; Roostalu, U.; Skovbjerg, G.; Nielsen, D.A.G.; Ejdrup, A.L.; Pers, T.H.; Dmytriyeva, O.; Hecksher-Sørensen, J.; Gether, U.; Kohlmeier, K.A.; Clemmensen, C. GLP-1 and nicotine combination therapy engages hypothalamic and mesolimbic pathways to reverse obesity. Cell Rep., 2023, 42(5), 112466.
[http://dx.doi.org/10.1016/j.celrep.2023.112466] [PMID: 37148870]

Borsook, D.; Linnman, C.; Faria, V.; Strassman, A.M.; Becerra, L.; Elman, I. Reward deficiency and anti-reward in pain chronification. Neurosci. Biobehav. Rev., 2016, 68, 282-297.
[http://dx.doi.org/10.1016/j.neubiorev.2016.05.033] [PMID: 27246519]

Blum, K.; McLaughlin, T.; Bowirrat, A.; Modestino, E.J.; Baron, D.; Gomez, L.L.; Ceccanti, M.; Braverman, E.R.; Thanos, P.K.; Cadet, J.L.; Elman, I.; Badgaiyan, R.D.; Jalali, R.; Green, R.; Simpatico, T.A.; Gupta, A.; Gold, M.S. Reward deficiency syndrome (RDS) surprisingly is evolutionary and found everywhere: Is it “blowin’in the wind”? J. Pers. Med., 2022, 12(2), 321.
[http://dx.doi.org/10.3390/jpm12020321] [PMID: 35207809]

Gruber, J.; Hanssen, R.; Qubad, M.; Bouzouina, A.; Schack, V.; Sochor, H.; Schiweck, C.; Aichholzer, M.; Matura, S.; Slattery, D.A.; Zopf, Y.; Borgland, S.L.; Reif, A.; Thanarajah, S.E. Impact of insulin and insulin resistance on brain dopamine signalling and reward processing – An underexplored mechanism in the pathophysiology of depression? Neurosci. Biobehav. Rev., 2023, 149, 105179.
[http://dx.doi.org/10.1016/j.neubiorev.2023.105179] [PMID: 37059404]

Gondré-Lewis, M.C.; Bassey, R.; Blum, K. Pre-clinical models of reward deficiency syndrome: A behavioral octopus. Neurosci. Biobehav. Rev., 2020, 115, 164-188.
[http://dx.doi.org/10.1016/j.neubiorev.2020.04.021] [PMID: 32360413]

Wilson, J.B.; Epstein, M.; Lopez, B.; Brown, A.K.; Lutfy, K.; Friedman, T.C. The role of neurochemicals, stress hormones and immune system in the positive feedback loops between diabetes, obesity and depression. Front. Endocrinol. (Lausanne), 2023, 14, 1224612.
[http://dx.doi.org/10.3389/fendo.2023.1224612] [PMID: 37664841]

Elman, I.; Borsook, D.; Volkow, N.D. Pain and suicidality: Insights from reward and addiction neuroscience. Prog. Neurobiol., 2013, 109, 1-27.
[http://dx.doi.org/10.1016/j.pneurobio.2013.06.003] [PMID: 23827972]

Blum, K.; Blum, K.; Febo, M.; Baron, D.; Modestino, E.J.; Elman, I.; Badgaiyan, R.D. Molecular role of dopamine in anhedonia linked to reward deficiency syndrome RDS and anti- reward systems. Front. Biosci. (Schol. Ed.), 2018, 10(2), 309-325.
[http://dx.doi.org/10.2741/s518] [PMID: 29293435]

Nephew, B.; Murgatroyd, C.; Pittet, F.; Febo, M. Brain reward pathway dysfunction in maternal depression and addiction: A present and future transgenerational risk. J. Reward Defic. Syndr., 2015, 1(3), 105-116.
[http://dx.doi.org/10.17756/jrds.2015-017] [PMID: 27617302]

Arango-Lievano, M.; Kaplitt, M.G. Comorbidity between depression and addiction-Towards a common molecular target? Med. Sci., 2015, 3(5), 546-550.

Zhao, X.; Wu, S.; Li, X.; Liu, Z.; Lu, W.; Lin, K.; Shao, R. Common neural deficits across reward functions in major depression: A meta-analysis of fMRI studies. Psychol. Med., 2024, 54(11), 2794-2806.
[http://dx.doi.org/10.1017/S0033291724001235] [PMID: 38777630]

Must, A.; Szabó, Z.; Bódi, N.; Szász, A.; Janka, Z.; Kéri, S. Sensitivity to reward and punishment and the prefrontal cortex in major depression. J. Affect. Disord., 2006, 90(2-3), 209-215.
[http://dx.doi.org/10.1016/j.jad.2005.12.005] [PMID: 16412520]

Salamone, J.D.; Correa, M.; Yohn, S.; Lopez Cruz, L.; San Miguel, N.; Alatorre, L. The pharmacology of effort-related choice behavior: Dopamine, depression, and individual differences. Behav. Processes, 2016, 127, 3-17.
[http://dx.doi.org/10.1016/j.beproc.2016.02.008] [PMID: 26899746]

Park, I.H.; Lee, B.C.; Kim, J.J.; Kim, J.I.; Koo, M.S. Effort-based reinforcement processing and functional connectivity underlying amotivation in medicated patients with depression and schizophrenia. J. Neurosci., 2017, 37(16), 4370-4380.
[http://dx.doi.org/10.1523/JNEUROSCI.2524-16.2017] [PMID: 28283562]

Sapuram, V.R.; Vrshek-Schallhorn, S.; Hilt, L.M.; Stroud, C.B. Dopaminergic genetic variation in young adolescents: Associations with sensation-seeking. Res. Child Adolesc. Psychopathol., 2021, 49(10), 1259-1274.
[http://dx.doi.org/10.1007/s10802-021-00823-y] [PMID: 33963956]

Bergamini, G.; Sigrist, H.; Ferger, B.; Singewald, N.; Seifritz, E.; Pryce, C.R. Depletion of nucleus accumbens dopamine leads to impaired reward and aversion processing in mice: Relevance to motivation pathologies. Neuropharmacology, 2016, 109, 306-319.
[http://dx.doi.org/10.1016/j.neuropharm.2016.03.048] [PMID: 27036890]

Lutz, P.E.; Kieffer, B.L. Opioid receptors: Distinct roles in mood disorders. Trends Neurosci., 2013, 36(3), 195-206.
[http://dx.doi.org/10.1016/j.tins.2012.11.002] [PMID: 23219016]

Wolters, E.C.; van der Werf, Y.D.; van den Heuvel, O.A. Parkinson’s disease-related disorders in the impulsive-compulsive spectrum. J. Neurol., 2008, 255(S5)(Suppl. 5), 48-56.
[http://dx.doi.org/10.1007/s00415-008-5010-5] [PMID: 18787882]

Thanos, P.K.; Blum, K.; McCarthy, M.; Senior, D.; Watts, S.; Connor, C.; Hammond, N.; Hadjiargyrou, M.; Komatsu, D.; Steiner, H. Combined chronic oral methylphenidate and fluoxetine treatment during adolescence: Effects on behavior. Curr. Pharm. Biotechnol., 2023, 24(10), 1307-1314.
[http://dx.doi.org/10.2174/1389201024666221028092342] [PMID: 36306463]

Rothman, R.B.; Blough, B.E.; Baumann, M.H. Dual dopamine/serotonin releasers as potential medications for stimulante and alcohol addictions. AAPS J., 2007, 9(1), E1-E10.
[http://dx.doi.org/10.1208/aapsj0901001] [PMID: 17408232]

Ribeiro, G.; Maia, A.; Cotovio, G.; Oliveira, F.P.M.; Costa, D.C.; Oliveira-Maia, A.J. Striatal dopamine D2-like receptors availability in obesity and its modulation by bariatric surgery: A systematic review and meta-analysis. Sci. Rep., 2023, 13(1), 4959.
[http://dx.doi.org/10.1038/s41598-023-31250-2] [PMID: 36973321]

Kanoski, S.E.; Hayes, M.R.; Skibicka, K.P. GLP-1 and weight loss: Unraveling the diverse neural circuitry. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2016, 310(10), R885-R895.
[http://dx.doi.org/10.1152/ajpregu.00520.2015] [PMID: 27030669]

Yorgason, J.T.; Wadsworth, H.A.; Anderson, E.J.; Williams, B.M.; Brundage, J.N.; Hedges, D.M.; Stockard, A.L.; Jones, S.T.; Arthur, S.B.; Hansen, D.M.; Schilaty, N.D.; Jang, E.Y.; Lee, A.M.; Wallner, M.; Steffensen, S.C. Modulation of dopamine release by ethanol is mediated by atypical GABAA receptors on cholinergic interneurons in the nucleus accumbens. Addict. Biol., 2022, 27(1), e13108.
[http://dx.doi.org/10.1111/adb.13108] [PMID: 34713509]

EMA statement on ongoing review of GLP-1 receptor agonists. 2023. Available from : https://www.ema.europa.eu/en/news/ema-statement-ongoing-review-glp-1-receptor-agonists

Terhune, R.R.C. Wegovy, other weight-loss drugs scrutinized over reports of suicidal thoughts., 2023. Available from: https://www.reuters.com/business/healthcare-pharmaceuticals/wegovy-other-weight-loss-drugs-scrutinized-over-reports-suicidal-thoughts-2023-09-28/

Ruggiero, R.; Mascolo, A.; Spezzaferri, A.; Carpentieri, C.; Torella, D.; Sportiello, L.; Rossi, F.; Paolisso, G.; Capuano, A. Glucagon-like Peptide-1 receptor agonists and suicidal ideation: Analysis of real-word data collected in the European Pharmacovigilance database. Pharmaceuticals, 2024, 17(2), 147.
[http://dx.doi.org/10.3390/ph17020147] [PMID: 38399362]

Tobaiqy, M.; Elkout, H. Psychiatric adverse events associated with semaglutide, liraglutide and tirzepatide: A pharmacovigilance analysis of individual case safety reports submitted to the EudraVigilance database. Int. J. Clin. Pharm., 2024, 46(2), 488-495.
[http://dx.doi.org/10.1007/s11096-023-01694-7] [PMID: 38265519]

Maideen, N.M.P.; Al Rashid, S. Suicidal thoughts and self-injurious behavior associated with glucagon-like peptide-1 receptor agonists - A review. Curr. Drug Saf., 2024, 19.
[http://dx.doi.org/10.2174/0115748863301925240507044637] [PMID: 38766830]

Salvo, F.; Faillie, J.L. GLP-1 receptor agonists and suicidality—caution is needed. JAMA Netw. Open, 2024, 7(8), e2423335-e2423335.
[http://dx.doi.org/10.1001/jamanetworkopen.2024.23335] [PMID: 39163050]

Driggin, E.; Goyal, P. Malnutrition and Sarcopenia as reasons for caution with GLP-1 receptor agonist use in HFpEF. J. Card. Fail., 2024, 30(4), 610-612.
[http://dx.doi.org/10.1016/j.cardfail.2024.01.005] [PMID: 38301742]

Scheen, A.J. Antidiabetic agents and risk of atrial fibrillation/flutter: A comparative critical analysis with a focus on differences between SGLT2 inhibitors and GLP-1 receptor agonists. Diabetes Metab., 2022, 48(6), 101390.
[http://dx.doi.org/10.1016/j.diabet.2022.101390] [PMID: 36170946]

Leehey, D.J.; Rahman, M.A.; Borys, E.; Picken, M.M.; Clise, C.E. Acute kidney injury associated with semaglutide. Kidney Med., 2021, 3(2), 282-285.
[http://dx.doi.org/10.1016/j.xkme.2020.10.008] [PMID: 33851124]

Sun, Y.; Fan, L.; Meng, J.; Zhang, F.; Zhang, D.; Mei, Q. Should GLP-1 receptor agonists be used with caution in high risk population for colorectal cancer? Med. Hypotheses, 2014, 82(3), 255-256.
[http://dx.doi.org/10.1016/j.mehy.2013.11.034] [PMID: 24424394]

Borab, Z.M.; Fisher, S.M.; Borab, Z.M.; Gimenez, A.; Raskin, P.; Valek, T.; Rohrich, R.J. Emerging role of Semaglutide and GLP-1 agonist medications in plastic surgery: A note of caution. Plast. Reconstr. Surg., 2021, 154(3), 629-631.
[http://dx.doi.org/10.1097/PRS.0000000000011418]

Nohara, H.; Nakashima, R.; Kamei, S.; Fujikawa, H.; Ueno-Shuto, K.; Kawakami, T.; Eto, Y.; Suico, M.A.; Li, J.D.; Kai, H.; Shuto, T. Intratracheal GLP-1 receptor agonist treatment up-regulates mucin via p38 and exacerbates emphysematous phenotype in mucus hypersecretory obstructive lung diseases. Biochem. Biophys. Res. Commun., 2020, 524(2), 332-339.
[http://dx.doi.org/10.1016/j.bbrc.2020.01.081] [PMID: 31996306]

Nguyen, A.; Smith, E.; Hashemy, H.; Agarwal, S.M.; Hahn, M.K.; Paterson, A.D.; Dash, S. Glucagon‐like‐peptide 1 receptor agonism and attempted suicide: A Mendelian randomisation study to assess a potential causal association. Clin. Obes., 2024, 14(4), e12676.
[http://dx.doi.org/10.1111/cob.12676] [PMID: 38778795]

Zhou, J.; Zheng, Y.; Xu, B.; Long, S.; Zhu, L.; Liu, Y.; Li, C.; Zhang, Y.; Liu, M.; Wu, X. Exploration of the potential association between GLP-1 receptor agonists and suicidal or self-injurious behaviors: A pharmacovigilance study based on the FDA Adverse Event Reporting System database. BMC Med., 2024, 22(1), 65.
[http://dx.doi.org/10.1186/s12916-024-03274-6] [PMID: 38355513]

Wang, W.; Volkow, N.D.; Berger, N.A.; Davis, P.B.; Kaelber, D.C.; Xu, R. Association of semaglutide with risk of suicidal ideation in a real-world cohort. Nat. Med., 2024, 30(1), 168-176.
[http://dx.doi.org/10.1038/s41591-023-02672-2] [PMID: 38182782]

Aschenbrenner, D.S. Preliminary review finds no link between GLP-1 receptor agonists and suicidality. Am. J. Nurs., 2024, 124(5), 20.
[http://dx.doi.org/10.1097/01.NAJ.0001016352.54091.a1] [PMID: 38661695]

Plum, L.; Belgardt, B.F.; Brüning, J.C. Central insulin action in energy and glucose homeostasis. J. Clin. Invest., 2006, 116(7), 1761-1766.
[http://dx.doi.org/10.1172/JCI29063] [PMID: 16823473]

Patti, M.E.; Butte, A.J.; Crunkhorn, S.; Cusi, K.; Berria, R.; Kashyap, S.; Miyazaki, Y.; Kohane, I.; Costello, M.; Saccone, R.; Landaker, E.J.; Goldfine, A.B.; Mun, E.; DeFronzo, R.; Finlayson, J.; Kahn, C.R.; Mandarino, L.J. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc. Natl. Acad. Sci. USA, 2003, 100(14), 8466-8471.
[http://dx.doi.org/10.1073/pnas.1032913100] [PMID: 12832613]

Gardner, A.; Boles, R.G. Beyond the serotonin hypothesis: Mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2011, 35(3), 730-743.
[http://dx.doi.org/10.1016/j.pnpbp.2010.07.030] [PMID: 20691744]

Agarwal, S.M.; Caravaggio, F.; Costa-Dookhan, K.A.; Castellani, L.; Kowalchuk, C.; Asgariroozbehani, R.; Graff-Guerrero, A.; Hahn, M. Brain insulin action in schizophrenia: Something borrowed and something new. Neuropharmacology, 2020, 163, 107633.
[http://dx.doi.org/10.1016/j.neuropharm.2019.05.010] [PMID: 31077731]

Nag, M. Effect of chlorpromazine, imipramine and lithium on MAO-A and MAO-B activity in rat brain mitochondria. Indian J. Exp. Biol., 2004, 42(9), 941-944.
[PMID: 15462192]

Herculano-Houzel, S. The glia/neuron ratio: How it varies uniformly across brain structures and species and what that means for brain physiology and evolution. Glia, 2014, 62(9), 1377-1391.
[http://dx.doi.org/10.1002/glia.22683] [PMID: 24807023]

Kleinridders, A.; Cai, W.; Cappellucci, L.; Ghazarian, A.; Collins, W.R.; Vienberg, S.G.; Pothos, E.N.; Kahn, C.R. Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. Proc. Natl. Acad. Sci. USA, 2015, 112(11), 3463-3468.
[http://dx.doi.org/10.1073/pnas.1500877112] [PMID: 25733901]

Stuart, M.J.; Baune, B.T. Depression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity. Neurosci. Biobehav. Rev., 2012, 36(1), 658-676.
[http://dx.doi.org/10.1016/j.neubiorev.2011.10.001] [PMID: 22020230]

Sadek, M.A.; Kandil, E.A.; El Sayed, N.S.; Sayed, H.M.; Rabie, M.A. Semaglutide, a novel glucagon-like peptide-1 agonist, amends experimental autoimmune encephalomyelitis-induced multiple sclerosis in mice: Involvement of the PI3K/Akt/GSK-3β pathway. Int. Immunopharmacol., 2023, 115, 109647.
[http://dx.doi.org/10.1016/j.intimp.2022.109647] [PMID: 36584570]

Schoretsanitis, G.; Weiler, S.; Barbui, C.; Raschi, E.; Gastaldon, C. Disproportionality analysis from World Health Organization data on semaglutide, liraglutide, and suicidality. JAMA Netw. Open, 2024, 7(8), e2423385-e2423385.
[http://dx.doi.org/10.1001/jamanetworkopen.2024.23385] [PMID: 39163046]

Blum, K.; Madigan, M.A.; Fuehrlein, B.; Thanos, P.K.; Lewandrowski, K.U.; Sharafshah, A.; Elman, I.; Baron, D.; Bowirrat, A.; Pinhasov, A.; Braverman, E.R.; Zeine, F.; Jafari, N.; Gold, M.S. Genes and Genetic Testing in Addiction Medicine., 2024. https://www.sciencedirect.com/referencework/9780128093245/reference-module-in-neuroscience-and-biobehavioral-psychology eferenceModule in Neuroscience and Biobehavioral Psychology

Tobaiqy, M.; Elkout, H. Psychiatric adverse events associated with semaglutide, liraglutide and tirzepatide: A pharmacovigilance analysis of individual case safety reports submitted to the EudraVigilance database. Int. J. Clin. Pharm., 2024, 46(2), 488-495.
[http://dx.doi.org/10.1007/s11096-023-01694-7] [PMID: 38265519]

Chen, W.; Cai, P.; Zou, W.; Fu, Z. Psychiatric adverse events associated with GLP-1 receptor agonists: A real-world pharmacovigilance study based on the FDA Adverse event reporting system database. Front. Endocrinol. (Lausanne), 2024, 15, 1330936.
[http://dx.doi.org/10.3389/fendo.2024.1330936] [PMID: 38390214]