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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

The Application of the Pyrazole Structure in the Structural Modification of Natural Products

In Press, (this is not the final "Version of Record"). Available online 21 January, 2025
Author(s): Fu-Qun Sun, Ya-Lan Wang, Ke Sun, Fei-Xia Yue, Yun-Xia Sun, Jia-Hong Ju, Zhan-Hui Jin, Qing-Kun Shen, Hong-Yan Guo, Mei-Hui Liu and Zhe-Shan Quan*
Published on: 21 January, 2025

DOI: 10.2174/0113895575359419241211092252

Price: $95

Abstract

Most natural products in nature have broad but not exceedingly good biological activities. The pyrazole structure has been introduced into natural products due to its suitability for various synthetic methods and its broad pharmacological activities. This article provides a detailed introduction to the anti-inflammatory, antibacterial, antifungal, antiviral, and anti-Alzheimer disease activities of pyrazole-modified natural product derivatives, particularly their anti-tumor activity. It is worth noting that compared to lead compounds, most natural product derivatives modified with pyrazole exhibit excellent pharmacological activity. Some of these derivatives exhibit outstanding anti-tumor activity, with IC50 values reaching nanomolar levels. This review provides more research directions and choices for future studies on natural products.

Keywords: Pyrazole, natural products, structural modification, biological activity.


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