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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Drug Repurposing: A Conduit to Unravelling Metabolic Reprogramming for Cancer Treatment

In Press, (this is not the final "Version of Record"). Available online 17 January, 2025
Author(s): Shristy Chaudhary, Abhilash Rana and Seema Bhatnagar*
Published on: 17 January, 2025

DOI: 10.2174/0113895575339660250106093738

Price: $95

Abstract

Metabolic reprogramming is a hallmark of cancer. Distinct and unusual metabolic aberrations occur during tumor development that lead to the growth and development of tumors. Oncogenic signaling pathways eventually converge to regulate three major metabolic pathways in tumor cells i.e., glucose, lipid, and amino acid metabolism. Therefore, identifying and targeting the metabolic nodes of cancer cells can be a promising intervention and therapeutic strategy for patients with malignancies. The long road of new drug discovery for cancer therapy has necessitated relooking alternative strategies such as drug repurposing. Advanced genomic and proteomic technologies for the assessment of cancer-specific biological pathways have led to the discovery of new drug targets, which provide excellent opportunities for drug repurposing. The development of effective, safe, cheaper, and readily available anticancer agents is the need of the hour, and drug repurposing has the potential to break the current drug shortage bottleneck. This review will accordingly cover various metabolic pathways that are aberrant in cancer, and strategies for targeting metabolic reprogramming by using repurposed drugs.

Keywords: Drug repurposing, cancer, metabolic reprogramming, cancer treatment, cancer metabolism, cell deathh


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